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Tbio
FPGT
Fucose-1-phosphate guanylyltransferase

Protein Summary
Description
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-pho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370894
  • ENSP00000359931
  • ENSG00000254685
  • ENST00000370898
  • ENSP00000359935
  • ENST00000534056
  • ENSP00000432819

Symbol
  • GFPP
  • GFPP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
molecular function
0.88
virus perturbation
0.64
cell line
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
TSTA3
Tbio
Family:  Enzyme
Novelty:  0.03669619
Score:  0.979
Data Source:  STRINGDB
FUK
Tbio
Family:  Kinase
Novelty:  0.05169095
Score:  0.941
Data Source:  STRINGDB
LRRIQ3
Tdark
Novelty:  0.63243484
Score:  0.752
Data Source:  STRINGDB
GMDS
Tbio
Family:  Enzyme
Novelty:  0.00622275
Score:  0.741
Data Source:  STRINGDB
ZC3H10
Tbio
Novelty:  0.22647282
Score:  0.67
Data Source:  STRINGDB
GMPPA
Tbio
Family:  Enzyme
Novelty:  0.14050797
Score:  0.646
Data Source:  STRINGDB
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
Score:  0.636
Data Source:  STRINGDB
ESYT1
Tbio
Novelty:  0.03069611
Score:  0.633
Data Source:  STRINGDB
RBM6
Tbio
Novelty:  0.06349982
Score:  0.632
Data Source:  STRINGDB
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
Score:  0.632
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
GDP-fucose biosynthesis
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
GDP-fucose biosynthesis
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
29
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1922790
75540
Rat
RGD:735121
310935
Dog
fucose-1-phosphate guanylyltransferase
VGNC:40974
100533995
Cow
fucose-1-phosphate guanylyltransferase
VGNC:29109
100138313
Pig
fucose-1-phosphate guanylyltransferase
100513664
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fucose-1-phosphate guanylyltransferase
Cow
fucose-1-phosphate guanylyltransferase
Pig
fucose-1-phosphate guanylyltransferase
Publication Statistics
PubMed Score 17.43
PubMed score by year
PubTator Score 6.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title