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Tbio
MEIS2
Homeobox protein Meis2

Protein Summary
Description
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314177
  • ENSP00000326296
  • ENSG00000134138
  • ENST00000338564
  • ENSP00000341400
  • ENST00000340545
  • ENSP00000339549
  • ENST00000397620
  • ENSP00000380745
  • ENST00000397624
  • ENSP00000380749
  • ENST00000424352
  • ENSP00000404185
  • ENST00000557796
  • ENSP00000452693
  • ENST00000559085
  • ENSP00000453390
  • ENST00000559561
  • ENSP00000453497
  • ENST00000561208
  • ENSP00000453793

Symbol
  • MRG1
  • MRG1
  • CPCMR
  • HsT18361
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
PubMedID
0.95
kinase perturbation
0.91
transcription factor
0.91
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.15   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.15   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (107)
1 – 10 of 107
MEIS3P1
Tdark
p_int:  1
Data Source:  BioPlex
MAB21L1
Tbio
Novelty:  0.07438538
p_int:  0.999999999
p_ni:  1e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
PBX3
Tbio
Family:  TF
Novelty:  0.01516183
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
PBX4
Tbio
Family:  TF
Novelty:  0.09471693
p_int:  0.999999981
p_ni:  1.5e-8
p_wrong:  5e-9
Score:  0.606
Data Source:  BioPlex,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.99999998
p_ni:  2.1e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
MAB21L2
Tbio
Novelty:  0.05770595
p_int:  0.999999893
p_ni:  8.5e-8
p_wrong:  2.3e-8
Score:  0.84
Data Source:  BioPlex,STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
p_int:  0.999999839
p_ni:  1.62e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  0.999999582
p_ni:  4.17e-7
p_wrong:  1e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
p_int:  0.999999486
p_ni:  5.14e-7
Score:  0.957
Data Source:  BioPlex,STRINGDB
FAM222A
Tdark
Novelty:  0.41466126
p_int:  0.999998619
p_ni:  0.000001373
p_wrong:  9e-9
Score:  0.859
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (22)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
31.4
chronotype measurement
1
1
1
29
self reported educational attainment
1
1
1
4.9
mathematical ability
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
31.4
chronotype measurement
1
29
self reported educational attainment
1
4.9
mathematical ability
1
0.3
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Meis homeobox 2
VGNC:3536
453312
Macaque
Meis homeobox 2
699748
Mouse
MGI:108564
17536
Rat
RGD:1305198
311311
Dog
Meis homeobox 2
VGNC:43154
612759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Meis homeobox 2
Macaque
Meis homeobox 2
Mouse
Rat
Dog
Meis homeobox 2
Publication Statistics
PubMed Score 81.15
PubMed score by year
PubTator Score 32.11
PubTator score by year