Tbio MEIS2 Homeobox protein Meis2

Protein Summary

Description

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14770
• A6NJI5
• A8MWD5
• B3KP98
• B3KPQ6
• Q96DI2
• Q96KI4
• Q96KI5
• Q9NRS1
• Q9NRS2
• Q9NRS3

Gene Name

• MEIS2

Ensembl ID

• ENST00000314177
• ENSP00000326296
• ENSG00000134138
• ENST00000338564
• ENSP00000341400
• ENST00000340545
• ENSP00000339549
• ENST00000397620
• ENSP00000380745
• ENST00000397624
• ENSP00000380749
• ENST00000424352
• ENSP00000404185
• ENST00000557796
• ENSP00000452693
• ENST00000559085
• ENSP00000453390
• ENST00000559561
• ENSP00000453497
• ENST00000561208
• ENSP00000453793

Symbol

• MRG1
• MRG1
• CPCMR
• HsT18361

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
PubMedID	0.95
kinase perturbation	0.91
transcription factor	0.91
molecular function	0.9

Protein Classes

PANTHER Classes

Protein / ... / Homeodomain Transcription Factor / Homeobox Protein Meis2

Protein / ... / Rna Binding Protein / Dna-directed Rna Polymerase / Homeobox Protein Meis2

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Homeobox Protein Meis2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.39   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.39   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0