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Tclin
GABRD
Gamma-aminobutyric acid receptor subunit delta

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378585
  • ENSP00000367848
  • ENSG00000187730

Symbol
  • EJM7
  • EIG10
  • GEFSP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.9
protein domain
0.85
phenotype
0.7
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.78   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.78   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Approved Drugs (13)
1 – 10 of 13
halothane
chemical structure image
isoflurane
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
methoxyflurane
chemical structure image
metharbital
chemical structure image
talbutal
chemical structure image
triclofos
chemical structure image
thiamylal
chemical structure image
halazepam
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor delta subunit
VGNC:8040
747186
Mouse
MGI:95622
14403
Rat
RGD:61901
29689
Dog
gamma-aminobutyric acid type A receptor delta subunit
VGNC:41061
489609
Horse
gamma-aminobutyric acid type A receptor delta subunit
VGNC:18199
100064300
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor delta subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor delta subunit
Horse
gamma-aminobutyric acid type A receptor delta subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14764-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
GABAergic synapse
KEGG
Nicotine addiction
KEGG
Neuroactive ligand-receptor interaction
KEGG
Morphine addiction
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
GABAergic synapse
Nicotine addiction
Neuroactive ligand-receptor interaction
Morphine addiction
Protein-Protein Interactions (204)
1 – 10 of 204
DNAJC18
Tdark
Novelty: 1.38573997
p_int: 0.999253285
p_ni: 0.000746704
p_wrong: 1.1e-8
Data Source: BioPlex
FUT8
Tbio
Family: Enzyme
Novelty: 0.00675388
p_int: 0.99816816
p_ni: 0.00183184
Data Source: BioPlex
SIDT2
Tbio
Novelty: 0.07560652
p_int: 0.989600553
p_ni: 0.009060507
p_wrong: 0.00133894
Score: 0.185
Data Source: BioPlex,STRINGDB
ST7L
Tbio
Novelty: 0.03661324
p_int: 0.982791603
p_ni: 0.016710466
p_wrong: 0.000497931
Data Source: BioPlex
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.976604033
p_ni: 0.0187935
p_wrong: 0.004602467
Data Source: BioPlex
TTC17
Tdark
Novelty: 0.79373597
p_int: 0.968787854
p_ni: 0.031212146
Data Source: BioPlex
CCPG1
Tbio
Novelty: 0.07685013
p_int: 0.953419277
p_ni: 0.046580723
Data Source: BioPlex
ATG9A
Tbio
Novelty: 0.01995033
p_int: 0.951993113
p_ni: 0.04800687
p_wrong: 1.7e-8
Data Source: BioPlex
DNAJB9
Tbio
Novelty: 0.00536296
p_int: 0.924549525
p_ni: 0.075450474
p_wrong: 1e-9
Data Source: BioPlex
TMEM131
Tdark
Novelty: 0.02152783
p_int: 0.902725342
p_ni: 0.097274658
Score: 0.194
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  57.78

PubMed score by year
PubTator Score  14.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer