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Tclin
GABRD
Gamma-aminobutyric acid receptor subunit delta

Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378585
  • ENSP00000367848
  • ENSG00000187730

Symbol
  • EJM7
  • EIG10
  • GEFSP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.9
protein domain
0.85
phenotype
0.7
disease perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.21   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.21   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (204)
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.999253285
p_ni:  0.000746704
p_wrong:  1.1e-8
Data Source:  BioPlex
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.99816816
p_ni:  0.00183184
Data Source:  BioPlex
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.989600553
p_ni:  0.009060507
p_wrong:  0.00133894
Score:  0.185
Data Source:  BioPlex,STRINGDB
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.982791603
p_ni:  0.016710466
p_wrong:  0.000497931
Data Source:  BioPlex
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.976604033
p_ni:  0.0187935
p_wrong:  0.004602467
Data Source:  BioPlex
TTC17
Tdark
Novelty:  0.79373597
p_int:  0.968787854
p_ni:  0.031212146
Data Source:  BioPlex
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.953419277
p_ni:  0.046580723
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.951993113
p_ni:  0.04800687
p_wrong:  1.7e-8
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.924549525
p_ni:  0.075450474
p_wrong:  1e-9
Data Source:  BioPlex
TMEM131
Tdark
Novelty:  0.02152783
p_int:  0.902725342
p_ni:  0.097274658
Score:  0.194
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
GABAergic synapse
KEGG
Nicotine addiction
KEGG
Neuroactive ligand-receptor interaction
KEGG
Morphine addiction
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
GABAergic synapse
Nicotine addiction
Neuroactive ligand-receptor interaction
Morphine addiction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
78.7
influenza A (H1N1)
1
1
0
16.9
36.9
risk-taking behaviour
1
1
1
21.5
lifestyle measurement
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.7
influenza A (H1N1)
0
16.9
36.9
risk-taking behaviour
1
21.5
lifestyle measurement
1
13.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor delta subunit
VGNC:8040
747186
Mouse
MGI:95622
14403
Rat
RGD:61901
29689
Dog
gamma-aminobutyric acid type A receptor delta subunit
VGNC:41061
489609
Horse
gamma-aminobutyric acid type A receptor delta subunit
VGNC:18199
100064300
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor delta subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor delta subunit
Horse
gamma-aminobutyric acid type A receptor delta subunit
Publication Statistics
PubMed Score 62.21
PubMed score by year
PubTator Score 14.94
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title