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Tbio
TNFRSF10B
Tumor necrosis factor receptor superfamily member 10B

Protein Summary
Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276431
  • ENSP00000276431
  • ENSG00000120889
  • ENST00000347739
  • ENSP00000317859

Symbol
  • DR5
  • KILLER
  • TRAILR2
  • TRICK2
  • ZTNFR9
  • DR5
  • CD262
  • KILLER
  • TRICK2
  • TRICKB
  • ZTNFR9
  • TRAILR2
  • TRICK2A
  • TRICK2B
  • TRAIL-R2
  • KILLER/DR5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
chemical
0.93
small molecule perturbation
0.84
biological process
0.78
transcription factor perturbation
0.74


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Target Illumination GWAS Analytics (TIGA)
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2071.03   (req: < 5)
Gene RIFs: 261   (req: <= 3)
Antibodies: 1085   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2071.03   (req: >= 5)
Gene RIFs: 261   (req: > 3)
Antibodies: 1085   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TNF-related apoptosis-inducing ligand receptor 2 measurement
1
1
1
81.2
testosterone measurement
1
1
1
39.7
monocyte percentage of leukocytes
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TNF-related apoptosis-inducing ligand receptor 2 measurement
1
81.2
testosterone measurement
1
39.7
monocyte percentage of leukocytes
1
27
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10b
VGNC:3000
742898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10b
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (55)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cell surface interactions at the vascular wall
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cell surface interactions at the vascular wall
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (192)
1 – 10 of 192
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
p_int: 0.999999353
p_ni: 6.45e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FADD
Tbio
Novelty: 0.00137968
p_int: 0.999994362
p_ni: 0.000002204
p_wrong: 0.000003434
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SCAMP1
Tbio
Novelty: 0.03293648
p_int: 0.999125966
p_ni: 0.000818139
p_wrong: 0.000055896
Score: 0.205
Data Source: BioPlex,STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.998387622
p_ni: 0.001612378
Score: 0.954
Data Source: BioPlex,Reactome,STRINGDB
STX3
Tbio
Novelty: 0.01055819
p_int: 0.997067725
p_ni: 0.002535152
p_wrong: 0.000397123
Data Source: BioPlex
RNF149
Tdark
Family: Enzyme
Novelty: 0.64503076
p_int: 0.995281553
p_ni: 0.004718447
p_wrong: 1e-9
Score: 0.726
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.994748499
p_ni: 0.005251501
Data Source: BioPlex
ASIC1
Tchem
Family: IC
Novelty: 0.00705323
p_int: 0.992168991
p_ni: 0.007830424
p_wrong: 5.85e-7
Data Source: BioPlex
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.972110737
p_ni: 0.027889263
Score: 0.222
Data Source: BioPlex,STRINGDB
SLC15A4
Tbio
Family: Transporter
Novelty: 0.01325014
p_int: 0.967720948
p_ni: 0.003772373
p_wrong: 0.028506679
Data Source: BioPlex
Publication Statistics
PubMed Score  2071.03

PubMed score by year
PubTator Score  986.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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