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Tchem
CHEK1
Serine/threonine-protein kinase Chk1

Protein Summary
Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428830
  • ENSP00000412504
  • ENSG00000149554
  • ENST00000438015
  • ENSP00000388648
  • ENST00000524737
  • ENSP00000432890
  • ENST00000532449
  • ENSP00000481616
  • ENST00000534070
  • ENSP00000435371
  • ENST00000544373
  • ENSP00000442317

Symbol
  • CHK1
  • CHK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
biological process
0.99
drug perturbation
0.99
interacting protein
0.99


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1595.52   (req: < 5)
Gene RIFs: 355   (req: <= 3)
Antibodies: 1665   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1595.52   (req: >= 5)
Gene RIFs: 355   (req: > 3)
Antibodies: 1665   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 935
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
71.2
heel bone mineral density
2
2
2
63
serum alanine aminotransferase measurement
1
1
0
5.7
21.5
mean platelet volume
1
1
1
12.9
platelet count
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
71.2
heel bone mineral density
2
63
serum alanine aminotransferase measurement
0
5.7
21.5
mean platelet volume
1
12.9
platelet count
1
11.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
checkpoint kinase 1
VGNC:11294
739836
Mouse
MGI:1202065
12649
Rat
Dog
checkpoint kinase 1
VGNC:53319
609767
Horse
checkpoint kinase 1
VGNC:49356
100064353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
checkpoint kinase 1
Mouse
Rat
Dog
checkpoint kinase 1
Horse
checkpoint kinase 1
Protein Structure (133 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14757-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 133
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (52)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
DNA Double-Strand Break Repair
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CACAO
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (560)
1 – 10 of 560
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.999971987
p_ni:  0.000028006
p_wrong:  7e-9
Score:  0.156
Data Source:  BioPlex,STRINGDB
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
p_int:  0.999452122
p_ni:  0.000547878
Score:  0.256
Data Source:  BioPlex,STRINGDB
NAT9
Tbio
Family:  Enzyme
Novelty:  0.07036821
p_int:  0.998469685
p_ni:  0.001530315
Score:  0.228
Data Source:  BioPlex,STRINGDB
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.997014342
p_ni:  0.002985658
Data Source:  BioPlex
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.995981915
p_ni:  0.004018079
p_wrong:  6e-9
Score:  0.641
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.994315479
p_ni:  0.005684521
Data Source:  BioPlex
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.986318774
p_ni:  0.013681219
p_wrong:  6e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.985224669
p_ni:  0.014775306
p_wrong:  2.4e-8
Data Source:  BioPlex
LRRC6
Tbio
Novelty:  0.10994386
p_int:  0.968617994
p_ni:  0.031382004
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
BCL2L14
Tbio
Novelty:  0.03980069
p_int:  0.940957502
p_ni:  0.059042498
Score:  0.206
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  1595.52

PubMed score by year
PubTator Score  1106.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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