You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TERT
Telomerase reverse transcriptase

Protein Summary
Description
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifier ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310581
  • ENSP00000309572
  • ENSG00000164362
  • ENST00000334602
  • ENSP00000334346
  • ENST00000460137
  • ENSP00000425003

Symbol
  • EST2
  • TCS1
  • TRT
  • TP2
  • TRT
  • CMM9
  • EST2
  • TCS1
  • hTRT
  • DKCA2
  • DKCB4
  • hEST2
  • PFBMFT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.97
biological process
0.96
cellular component
0.95
hub protein
0.94
molecular function
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.56   (req: < 5)
Gene RIFs: 1526   (req: <= 3)
Antibodies: 909   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.56   (req: >= 5)
Gene RIFs: 1526   (req: > 3)
Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0