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Tchem
TERT
Telomerase reverse transcriptase

Protein Summary
Description
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifier ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310581
  • ENSP00000309572
  • ENSG00000164362
  • ENST00000334602
  • ENSP00000334346
  • ENST00000460137
  • ENSP00000425003

Symbol
  • EST2
  • TCS1
  • TRT
  • TP2
  • TRT
  • CMM9
  • EST2
  • TCS1
  • hTRT
  • DKCA2
  • DKCB4
  • hEST2
  • PFBMFT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.97
biological process
0.96
cellular component
0.95
hub protein
0.94
molecular function
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4362.3   (req: < 5)
Gene RIFs: 1526   (req: <= 3)
Antibodies: 909   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4362.3   (req: >= 5)
Gene RIFs: 1526   (req: > 3)
Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 170
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (74)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
0
1.3
97.9
6
4
2
1.2
97.2
neutrophil count
5
4
6
97.1
7
3
0
1.3
97
8
3
0
1.5
96.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.9
2
1.2
97.2
neutrophil count
6
97.1
0
1.3
97
0
1.5
96.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomerase reverse transcriptase
VGNC:4192
101058547
Macaque
telomerase reverse transcriptase
709865
Mouse
MGI:1202709
21752
Rat
RGD:70494
301965
Dog
telomerase reverse transcriptase
VGNC:47255
403412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomerase reverse transcriptase
Macaque
telomerase reverse transcriptase
Mouse
Rat
Dog
telomerase reverse transcriptase
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14746-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Extension of Telomeres
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Extension of Telomeres
Formation of the beta-catenin:TCF transactivating complex
Signal Transduction
Gene Ontology Terms (68)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (320)
1 – 10 of 320
DKC1
Tbio
Novelty:  0.00352181
Score:  0.994
Data Source:  Reactome,STRINGDB
SMARCA4
Tchem
Family:  Epigenetic
Novelty:  0.00112496
Score:  0.993
Data Source:  Reactome,STRINGDB
PINX1
Tbio
Family:  TF
Novelty:  0.01237398
Score:  0.991
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.989
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.989
Data Source:  STRINGDB
PIF1
Tbio
Family:  Enzyme
Novelty:  0.00449506
Score:  0.989
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.989
Data Source:  STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.988
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.985
Data Source:  STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4362.30

PubMed score by year
PubTator Score  3632.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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