Tchem SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Protein Summary

Description

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O14745
• B3KY21
• O43552
• Q86WQ5
• NHERF-1

Gene Name

• SLC9A3R1

Ensembl ID

• ENST00000262613
• ENSP00000262613
• ENSG00000109062
• ENST00000413388
• ENSP00000464982

Symbol

• NHERF
• NHERF1
• EBP50
• NHERF
• NHERF1
• NHERF-1
• NPHLOP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
disease perturbation	0.96
transcription factor perturbation	0.94
cellular component	0.86
transcription factor binding site profile	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.7   (req: < 5)

Gene RIFs: 164   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.7   (req: >= 5)

Gene RIFs: 164   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0