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Tchem
PRMT5
Protein arginine N-methyltransferase 5

Protein Summary
Description
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methyl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216350
  • ENSP00000216350
  • ENSG00000100462
  • ENST00000324366
  • ENSP00000319169
  • ENST00000397440
  • ENSP00000380582
  • ENST00000397441
  • ENSP00000380583
  • ENST00000553897
  • ENSP00000452555

Symbol
  • HRMT1L5
  • IBP72
  • JBP1
  • SKB1
  • HSL7
  • JBP1
  • SKB1
  • IBP72
  • SKB1Hs
  • HRMT1L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
kinase perturbation
0.93
hub protein
0.92
histone modification site profile
0.9
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.75   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 574   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.75   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 354
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0