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Tbio
PDCD5
Programmed cell death protein 5

Protein Classes
Protein Summary
Description
May function in the process of apoptosis. This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419343
  • ENSP00000476525
  • ENSG00000105185
  • ENST00000590247
  • ENSP00000466214

Symbol
  • TFAR19
  • TFAR19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
gene perturbation
0.78
biological process
0.77
histone modification site profile
0.75
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.18   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.18   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
PFDN5
Tbio
Novelty: 0.09272547
Score: 0.913
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.812
Data Source: STRINGDB
YAF2
Tbio
Novelty: 0.14775726
Score: 0.793
Data Source: STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00465028
Score: 0.789
Data Source: STRINGDB
PFDN6
Tbio
Novelty: 0.02635016
Score: 0.752
Data Source: STRINGDB
VBP1
Tbio
Novelty: 0.05609599
Score: 0.741
Data Source: STRINGDB
DBNDD1
Tdark
Novelty: 1.32352941
Score: 0.71
Data Source: STRINGDB
SNRPG
Tdark
Novelty: 0.75
Score: 0.701
Data Source: STRINGDB
PBDC1
Tdark
Novelty: 1.5
Score: 0.686
Data Source: STRINGDB
OTUD5
Tbio
Novelty: 0.10873083
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.18

PubMed score by year
PubTator Score  96.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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