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Tbio
PDCD5
Programmed cell death protein 5

Protein Classes
Protein Summary
Description
May function in the process of apoptosis. This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419343
  • ENSP00000476525
  • ENSG00000105185
  • ENST00000590247
  • ENSP00000466214

Symbol
  • TFAR19
  • TFAR19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
gene perturbation
0.78
biological process
0.77
histone modification site profile
0.75
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.39   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.39   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
81.7
mean corpuscular volume
1
1
1
38.6
mean reticulocyte volume
1
1
1
32.6
red blood cell distribution width
1
1
1
32.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
81.7
mean corpuscular volume
1
38.6
mean reticulocyte volume
1
32.6
red blood cell distribution width
1
32.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 5
VGNC:2292
455920
Macaque
programmed cell death 5
702277
Mouse
MGI:1913538
56330
Dog
programmed cell death 5
VGNC:44339
476499
Horse
programmed cell death 5
VGNC:21232
100629343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 5
Macaque
programmed cell death 5
Mouse
Dog
programmed cell death 5
Horse
programmed cell death 5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
PFDN5
Tbio
Novelty: 0.07673574
Score: 0.913
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.812
Data Source: STRINGDB
YAF2
Tbio
Novelty: 0.10772286
Score: 0.793
Data Source: STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
Score: 0.789
Data Source: STRINGDB
PFDN6
Tbio
Novelty: 0.01632101
Score: 0.752
Data Source: STRINGDB
VBP1
Tbio
Novelty: 0.0428293
Score: 0.741
Data Source: STRINGDB
DBNDD1
Tdark
Novelty: 0.60202124
Score: 0.71
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.701
Data Source: STRINGDB
PBDC1
Tdark
Novelty: 0.79983498
Score: 0.686
Data Source: STRINGDB
OTUD5
Tbio
Novelty: 0.0498487
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  130.39

PubMed score by year
PubTator Score  96.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer