Tbio ACOT8 Acyl-coenzyme A thioesterase 8

Protein Summary

Description

Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• O14734
• O15261
• Q17RX4
• Acyl-CoA thioesterase 8

Gene Name

• ACOT8

Ensembl ID

• ENST00000217455
• ENSP00000217455
• ENSG00000101473

Symbol

• ACTEIII
• PTE1
• PTE2
• hTE
• NAP1
• PTE1
• PTE2
• PTE-1
• PTE-2
• HNAACTE
• hACTE-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
histone modification site profile	0.86
kinase perturbation	0.81
disease perturbation	0.74
cell type or tissue	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Esterase / Acyl-coenzyme A Thioesterase 8

DTO Classes

Protein / Enzyme / Hydrolase / Esterase / Acyl-coenzyme A Thioesterase 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0