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Tbio
ACOT8
Acyl-coenzyme A thioesterase 8

Protein Summary
Description
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217455
  • ENSP00000217455
  • ENSG00000101473

Symbol
  • ACTEIII
  • PTE1
  • PTE2
  • hTE
  • NAP1
  • PTE1
  • PTE2
  • PTE-1
  • PTE-2
  • HNAACTE
  • hACTE-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
histone modification site profile
0.86
kinase perturbation
0.81
disease perturbation
0.74
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
14
14
25
99.7
triglyceride measurement
14
12
24
3.3
99.4
sleep duration
4
3
4
90.1
apolipoprotein B measurement
2
2
2
86.8
mean reticulocyte volume
1
1
1
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
25
99.7
triglyceride measurement
24
3.3
99.4
sleep duration
4
90.1
apolipoprotein B measurement
2
86.8
mean reticulocyte volume
1
83.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 8
VGNC:6030
458288
Macaque
acyl-CoA thioesterase 8
717238
Mouse
MGI:2158201
170789
Rat
RGD:70368
170588
Dog
acyl-CoA thioesterase 8
VGNC:37519
477247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA thioesterase 8
Macaque
acyl-CoA thioesterase 8
Mouse
Rat
Dog
acyl-CoA thioesterase 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14734-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Bile acid and bile salt metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Bile acid and bile salt metabolism
Fatty acid metabolism
Metabolism
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (103)
1 – 10 of 103
PML
Tbio
Novelty:  0.00285474
p_int:  0.999972054
p_ni:  0.000027946
Score:  0.519
Data Source:  BioPlex,STRINGDB
KLHL23
Tdark
Novelty:  0.64141058
p_int:  0.991070619
p_ni:  0.008915278
p_wrong:  0.000014103
Score:  0.332
Data Source:  BioPlex,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.873047806
p_ni:  0.126952194
Data Source:  BioPlex
IGHA1
Tbio
p_int:  0.776453201
p_ni:  0.223546799
Data Source:  BioPlex
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
Score:  0.991
Data Source:  STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
Score:  0.97
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.97
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.969
Data Source:  STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
Score:  0.967
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.22

PubMed score by year
PubTator Score  23.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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