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Tchem
MAP2K7
Dual specificity mitogen-activated protein kinase kinase 7

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397979
  • ENSP00000381066
  • ENSG00000076984
  • ENST00000397981
  • ENSP00000381068
  • ENST00000397983
  • ENSP00000381070

Symbol
  • JNKK2
  • MEK7
  • MKK7
  • PRKMK7
  • SKK4
  • MEK
  • MKK7
  • JNKK2
  • MEK 7
  • MAPKK7
  • PRKMK7
  • SAPKK4
  • SAPKK-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.95
transcription factor binding site profile
0.9
histone modification site profile
0.87
pathway
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4110.91   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4110.91   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
cobimetinib
chemical structure image
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (122)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (29)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (345)
1 – 10 of 345
IL13RA2
Tbio
Novelty: 0.04900852
p_int: 0.99802078
p_ni: 0.00197922
Data Source: BioPlex
LAMP3
Tbio
Novelty: 0.02024311
p_int: 0.995977143
p_ni: 0.004022854
p_wrong: 3e-9
Data Source: BioPlex
SPACA1
Tbio
Novelty: 0.14150943
p_int: 0.993891135
p_ni: 0.006088535
p_wrong: 0.000020329
Score: 0.191
Data Source: BioPlex,STRINGDB
PROZ
Tbio
Family: Enzyme
Novelty: 0.04928676
p_int: 0.992287246
p_ni: 0.007711016
p_wrong: 0.000001738
Data Source: BioPlex
TPCN2
Tchem
Family: IC
Novelty: 0.01836974
p_int: 0.944303247
p_ni: 0.055696753
Data Source: BioPlex
DLK1
Tchem
Novelty: 0.00168177
p_int: 0.940615001
p_ni: 0.059384984
p_wrong: 1.6e-8
Score: 0.237
Data Source: BioPlex,STRINGDB
C4BPB
Tbio
Novelty: 0.12609905
p_int: 0.910831821
p_ni: 0.089151125
p_wrong: 0.000017054
Score: 0.173
Data Source: BioPlex,STRINGDB
TACR3
Tchem
Family: GPCR
Novelty: 0.00322406
p_int: 0.903765686
p_ni: 0.096234227
p_wrong: 8.6e-8
Data Source: BioPlex
ANTXR1
Tbio
Novelty: 0.00562876
p_int: 0.894598626
p_ni: 0.105401369
p_wrong: 5e-9
Score: 0.489
Data Source: BioPlex,STRINGDB
BSG
Tbio
Novelty: 0.00077805
p_int: 0.878410021
p_ni: 0.121586535
p_wrong: 0.000003444
Score: 0.281
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4110.91

PubMed score by year
PubTator Score  2525.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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