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Tchem
MAP2K7
Dual specificity mitogen-activated protein kinase kinase 7

Protein Summary
Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397979
  • ENSP00000381066
  • ENSG00000076984
  • ENST00000397981
  • ENSP00000381068
  • ENST00000397983
  • ENSP00000381070

Symbol
  • JNKK2
  • MEK7
  • MKK7
  • PRKMK7
  • SKK4
  • MEK
  • MKK7
  • JNKK2
  • MEK 7
  • MAPKK7
  • PRKMK7
  • SAPKK4
  • SAPKK-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.95
transcription factor binding site profile
0.9
histone modification site profile
0.87
pathway
0.83


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.77   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.77   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
cobimetinib
Rendered image for cobimetinib
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
2
1
86.8
sex hormone-binding globulin measurement
4
1
4
67.3
high density lipoprotein cholesterol measurement
1
1
1
45.7
testosterone measurement
1
1
1
42.3
appendicular lean mass
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
86.8
sex hormone-binding globulin measurement
4
67.3
high density lipoprotein cholesterol measurement
1
45.7
testosterone measurement
1
42.3
appendicular lean mass
1
39.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 7
VGNC:7487
743199
Macaque
mitogen-activated protein kinase kinase 7
710077
Mouse
MGI:1346871
26400
Rat
RGD:1560043
363855
Dog
mitogen-activated protein kinase kinase 7
VGNC:42965
485004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase 7
Macaque
mitogen-activated protein kinase kinase 7
Mouse
Rat
Dog
mitogen-activated protein kinase kinase 7
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14733-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (122)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (29)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (345)
1 – 10 of 345
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.99802078
p_ni:  0.00197922
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.995977143
p_ni:  0.004022854
p_wrong:  3e-9
Data Source:  BioPlex
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.993891135
p_ni:  0.006088535
p_wrong:  0.000020329
Score:  0.191
Data Source:  BioPlex,STRINGDB
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.992287246
p_ni:  0.007711016
p_wrong:  0.000001738
Data Source:  BioPlex
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.944303247
p_ni:  0.055696753
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.940615001
p_ni:  0.059384984
p_wrong:  1.6e-8
Score:  0.237
Data Source:  BioPlex,STRINGDB
C4BPB
Tbio
Novelty:  0.0924866
p_int:  0.910831821
p_ni:  0.089151125
p_wrong:  0.000017054
Score:  0.173
Data Source:  BioPlex,STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.903765686
p_ni:  0.096234227
p_wrong:  8.6e-8
Data Source:  BioPlex
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.894598626
p_ni:  0.105401369
p_wrong:  5e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.878410021
p_ni:  0.121586535
p_wrong:  0.000003444
Score:  0.281
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  111.77

PubMed score by year
PubTator Score  2525.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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