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Tbio
IMPA2
Inositol monophosphatase 2

Protein Summary
Description
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269159
  • ENSP00000269159
  • ENSG00000141401

Symbol
  • IMP.18P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.81
PubMedID
0.8
kinase perturbation
0.71
gene perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.997746531
p_ni:  0.001579124
p_wrong:  0.000674345
Data Source:  BioPlex
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.984000907
p_ni:  0.015893948
p_wrong:  0.000105145
Score:  0.252
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.972674594
p_ni:  0.015152803
p_wrong:  0.012172602
Data Source:  BioPlex
RBFOX1
Tbio
Novelty:  0.00571285
p_int:  0.930268122
p_ni:  0.019030013
p_wrong:  0.050701865
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.928503605
p_ni:  0.00714906
p_wrong:  0.064347335
Score:  0.151
Data Source:  BioPlex,STRINGDB
A4GNT
Tbio
Family:  Enzyme
Novelty:  0.08971876
p_int:  0.812221957
p_ni:  0.012698722
p_wrong:  0.175079321
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.765034268
p_ni:  0.007995403
p_wrong:  0.226970328
Data Source:  BioPlex
IMPA1
Tclin
Family:  Enzyme
Novelty:  0.00766053
Score:  0.985
Data Source:  STRINGDB
ISYNA1
Tbio
Family:  Enzyme
Novelty:  0.00302974
Score:  0.966
Data Source:  STRINGDB
INPP1
Tbio
Family:  Enzyme
Novelty:  0.05426301
Score:  0.96
Data Source:  STRINGDB
Pathways (11)
Inositol phosphate metabolism (R-HSA-1483249)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP2, IP, and Ins in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP2, IP, and Ins in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
1
2
47.7
hematocrit
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
47.7
hematocrit
1
6.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase 2
VGNC:9913
455286
Mouse
MGI:2149728
114663
Rat
RGD:628692
282636
Dog
inositol monophosphatase 2
VGNC:49913
608801
Horse
inositol monophosphatase 2
VGNC:19050
100058669
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol monophosphatase 2
Mouse
Rat
Dog
inositol monophosphatase 2
Horse
inositol monophosphatase 2
Publication Statistics
PubMed Score 29.74
PubMed score by year
PubTator Score 48.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title