Tbio IMPA2 Inositol monophosphatase 2

Protein Summary

Description

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• O14732
• B0YJ29
• Q9UJT3
• IMP 2

Gene Name

• IMPA2

Ensembl ID

• ENST00000269159
• ENSP00000269159
• ENSG00000141401

Symbol

• IMP.18P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
transcription factor binding site profile	0.81
PubMedID	0.8
kinase perturbation	0.71
gene perturbation	0.69

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Inositol Monophosphatase 2

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Inositol Monophosphatase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0