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Tchem
RIOK3
Serine/threonine-protein kinase RIO3

Protein Summary
Description
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339486
  • ENSP00000341874
  • ENSG00000101782
  • ENST00000577501
  • ENSP00000462548

Symbol
  • SUDD
  • SUDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
0.99
molecular function
0.91
disease perturbation
0.87
small molecule perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.41   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.41   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
9
80.9
reticulocyte measurement
3
2
6
71.7
body weights and measures
1
1
1
41.1
waist-hip ratio
1
1
1
33.5
self reported educational attainment
1
1
1
27.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
80.9
reticulocyte measurement
6
71.7
body weights and measures
1
41.1
waist-hip ratio
1
33.5
self reported educational attainment
1
27.5
Pathways (9)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (145)
1 – 10 of 145
SLC2A13
Tbio
Family: Transporter
Novelty: 0.04641021
p_int: 0.999995102
p_ni: 0.000004822
p_wrong: 7.6e-8
Data Source: BioPlex
RIOK2
Tbio
Family: Kinase
Novelty: 0.02940435
Score: 0.991
Data Source: STRINGDB
PNO1
Tbio
Novelty: 0.05311566
Score: 0.977
Data Source: STRINGDB
NOB1
Tbio
Novelty: 0.01209681
Score: 0.971
Data Source: STRINGDB
LTV1
Tbio
Novelty: 0.04050879
Score: 0.968
Data Source: STRINGDB
MPHOSPH10
Tbio
Novelty: 0.04846226
Score: 0.956
Data Source: STRINGDB
BMS1
Tbio
Novelty: 0.0349992
Score: 0.95
Data Source: STRINGDB
BYSL
Tbio
Novelty: 0.01919968
Score: 0.95
Data Source: STRINGDB
UTP11
Tbio
Novelty: 0.20711838
Score: 0.943
Data Source: STRINGDB
DIEXF
Tbio
Novelty: 0.05892659
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.41

PubMed score by year
PubTator Score  10.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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