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Tbio
APAF1
Apoptotic protease-activating factor 1

Protein Summary
Description
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333991
  • ENSP00000334558
  • ENSG00000120868
  • ENST00000357310
  • ENSP00000349862
  • ENST00000359972
  • ENSP00000353059
  • ENST00000547045
  • ENSP00000449791
  • ENST00000550527
  • ENSP00000448449
  • ENST00000551964
  • ENSP00000448165
  • ENST00000552268
  • ENSP00000448826

Symbol
  • KIAA0413
  • CED4
  • APAF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
histone modification site profile
0.88
transcription factor perturbation
0.84
chemical
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 860.69   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 860.69   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
27.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptotic peptidase activating factor 1
VGNC:4926
452153
Macaque
apoptotic peptidase activating factor 1
694164
Mouse
MGI:1306796
11783
Rat
RGD:620575
78963
Horse
apoptotic peptidase activating factor 1
VGNC:15395
100052552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptotic peptidase activating factor 1
Macaque
apoptotic peptidase activating factor 1
Mouse
Rat
Horse
apoptotic peptidase activating factor 1
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14727-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (66)
Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Cytochrome c-mediated apoptotic response
Reactome
Formation of apoptosome
Name
Explore in Pharos
Explore in Source
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (223)
1 – 10 of 223
DEF8
Tdark
Novelty: 0.21146806
p_int: 0.999928773
p_ni: 0.00007122
p_wrong: 7e-9
Score: 0.18
Data Source: BioPlex,STRINGDB
OMD
Tbio
Novelty: 0.01992089
p_int: 0.999852449
p_ni: 0.000147534
p_wrong: 1.6e-8
Score: 0.24
Data Source: BioPlex,STRINGDB
WDFY3
Tbio
Novelty: 0.01670166
p_int: 0.998909639
p_ni: 0.001056403
p_wrong: 0.000033957
Score: 0.598
Data Source: BioPlex,STRINGDB
LINC01587
Tdark
Novelty: 0.48128342
p_int: 0.998869606
p_ni: 0.001099615
p_wrong: 0.000030779
Score: 0.185
Data Source: BioPlex,STRINGDB
ENDOV
Tbio
Family: Enzyme
Novelty: 0.00459706
p_int: 0.998815889
p_ni: 0.001073262
p_wrong: 0.000110849
Score: 0.52
Data Source: BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty: 0.43694835
p_int: 0.998753178
p_ni: 0.001245572
p_wrong: 0.00000125
Score: 0.366
Data Source: BioPlex,STRINGDB
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.998672192
p_ni: 0.001178338
p_wrong: 0.00014947
Data Source: BioPlex
LGALS7
Tbio
Novelty: 0.00753996
p_int: 0.961110685
p_ni: 0.018126619
p_wrong: 0.020762696
Score: 0.166
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.957474797
p_ni: 0.020189317
p_wrong: 0.022335886
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.952764951
p_ni: 0.018812392
p_wrong: 0.028422657
Data Source: BioPlex
Publication Statistics
PubMed Score  860.69

PubMed score by year
PubTator Score  435.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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