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Tbio
ITGB1BP1
Integrin beta-1-binding protein 1

Protein Summary
Description
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238091
  • ENSP00000238091
  • ENSG00000119185
  • ENST00000355346
  • ENSP00000347504
  • ENST00000360635
  • ENSP00000353850
  • ENST00000488451
  • ENSP00000419524

Symbol
  • ICAP1
  • ICAP1
  • ICAP1A
  • ICAP1B
  • ICAP-1A
  • ICAP-1B
  • ICAP-1alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.97
disease perturbation
0.96
histone modification site profile
0.89
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (57)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (52)
1 – 10 of 52
KRIT1
Tbio
Novelty: 0.0061615
p_int: 0.999998455
p_ni: 4e-9
p_wrong: 0.000001542
Score: 0.999
Data Source: BioPlex,STRINGDB
CCM2
Tbio
Novelty: 0.01158059
p_int: 0.999993146
p_ni: 8.3e-8
p_wrong: 0.000006771
Score: 0.954
Data Source: BioPlex,STRINGDB
ITGB1
Tclin
Novelty: 0.00074903
Score: 0.991
Data Source: STRINGDB
PDHX
Tbio
Family: Enzyme
Novelty: 0.0031605
Score: 0.713
Data Source: STRINGDB
CIPC
Tdark
Novelty: 0.00914554
Score: 0.7
Data Source: STRINGDB
VTA1
Tbio
Novelty: 0.02244131
Score: 0.673
Data Source: STRINGDB
ZNF410
Tbio
Family: TF
Novelty: 0.01904036
Score: 0.67
Data Source: STRINGDB
ASAP2
Tbio
Novelty: 0.06855272
Score: 0.665
Data Source: STRINGDB
NMBR
Tchem
Family: GPCR
Novelty: 0.01429048
Score: 0.655
Data Source: STRINGDB
HIVEP2
Tbio
Family: TF
Novelty: 0.03174474
Score: 0.654
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.23

PubMed score by year
PubTator Score  18.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer