Tbio ABCD4 ATP-binding cassette sub-family D member 4

Protein Summary

Description

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• O14678
• A8K5L7
• Q6IAQ0
• Q96E75

Gene Name

• ABCD4

Ensembl ID

• ENST00000356924
• ENSP00000349396
• ENSG00000119688

Symbol

• PXMP1L
• P70R
• P79R
• ABC41
• MAHCJ
• PMP69
• PXMP1L
• EST352188

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
transcription factor binding site profile	0.82
cellular component	0.79
protein domain	0.73
transcription factor	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette Sub-family D Member 4

DTO Classes

Protein / Transporter / Atp-binding Cassette Sub-family D Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.58   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.58   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0