Tchem ADAM10 Disintegrin and metalloproteinase domain-containing protein 10

Protein Summary

Description

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O14672
• B4DU28
• Q10742
• Q92650
• ADAM 10

Gene Name

• ADAM10

Ensembl ID

• ENST00000260408
• ENSP00000260408
• ENSG00000137845

Symbol

• KUZ
• MADM
• RAK
• kuz
• AD10
• AD18
• MADM
• CD156c
• CDw156
• HsT18717

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
transcription factor perturbation	0.96
molecular function	0.9
trait	0.86
virus perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 780.93   (req: < 5)

Gene RIFs: 328   (req: <= 3)

Antibodies: 526   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 780.93   (req: >= 5)

Gene RIFs: 328   (req: > 3)

Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 132

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0