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Tchem
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10

Protein Summary
Description
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260408
  • ENSP00000260408
  • ENSG00000137845

Symbol
  • KUZ
  • MADM
  • RAK
  • kuz
  • AD10
  • AD18
  • MADM
  • CD156c
  • CDw156
  • HsT18717
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
transcription factor perturbation
0.96
molecular function
0.9
trait
0.86
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.98   (req: < 5)
Gene RIFs: 255   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.98   (req: >= 5)
Gene RIFs: 255   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 128
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
65.3
family history of Alzheimer’s disease
1
1
0
6.1
40
1
1
0
6.1
40
apolipoprotein A 1 measurement
1
1
1
34.7
1
1
0
1.1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
65.3
family history of Alzheimer’s disease
0
6.1
40
0
6.1
40
apolipoprotein A 1 measurement
1
34.7
0
1.1
10.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 10
VGNC:1570
746942
Macaque
ADAM metallopeptidase domain 10
701355
Mouse
MGI:109548
11487
Rat
RGD:2032
29650
Dog
ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 10
Macaque
ADAM metallopeptidase domain 10
Mouse
Rat
Dog
ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188]
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (58)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Amyloid fiber formation
Reactome
Axon guidance
Reactome
Collagen degradation
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Amyloid fiber formation
Axon guidance
Collagen degradation
Constitutive Signaling by NOTCH1 HD Domain Mutants
Gene Ontology Terms (60)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (373)
1 – 10 of 373
HFE
Tbio
Novelty: 0.00042077
p_int: 0.96710221
p_ni: 0.03289779
Score: 0.244
Data Source: BioPlex,STRINGDB
NOG
Tbio
Novelty: 0.0010373
p_int: 0.789563613
p_ni: 0.210436372
p_wrong: 1.5e-8
Score: 0.222
Data Source: BioPlex,STRINGDB
IL7
Tbio
Novelty: 0.00054101
p_int: 0.757351096
p_ni: 0.242648899
p_wrong: 5e-9
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.755128502
p_ni: 0.244871496
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
DLL1
Tbio
Novelty: 0.00150384
Score: 0.99
Data Source: Reactome,STRINGDB
DLL4
Tbio
Novelty: 0.00263355
Score: 0.989
Data Source: Reactome,STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.989
Data Source: Reactome,STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.988
Data Source: Reactome,STRINGDB
TSPAN14
Tdark
Novelty: 0.31693614
Score: 0.982
Data Source: Reactome,STRINGDB
EFNA2
Tbio
Novelty: 0.01184859
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  654.98

PubMed score by year
PubTator Score  399.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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