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Tbio
TOR1B
Torsin-1B

Protein Classes
Protein Summary
Description
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. The protein encoded by this gene is an ATPase found primarily in the endoplasmic reticulum and nuclear envelope. This gene has a highly-similar neighboring gene, TOR1A, that encodes a protein that is likely to interact in a complex with this protein. Finally, this protein may act as a chaperone and play a role in maintaining the integrity of the nuclear envelope and endoplasmic reticulum. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259339
  • ENSP00000259339
  • ENSG00000136816

Symbol
  • DQ1
  • DQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.91
transcription factor perturbation
0.88
kinase perturbation
0.81
transcription factor binding site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
5.6
64.9
1
1
0
1.1
35
liver fat measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
5.6
64.9
0
1.1
35
liver fat measurement
1
29
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
torsin family 1 member B
VGNC:13982
742652
Macaque
torsin family 1 member B
716582
Mouse
MGI:1353605
30934
Rat
RGD:1308431
311854
Dog
torsin family 1 member B
VGNC:47714
100855798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
torsin family 1 member B
Macaque
torsin family 1 member B
Mouse
Rat
Dog
torsin family 1 member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14657-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (130)
1 – 10 of 130
FBXO6
Tbio
Novelty:  0.02173918
p_int:  0.997065533
p_ni:  0.002934467
Score:  0.181
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.996892019
p_ni:  0.003107981
Score:  0.212
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.985280669
p_ni:  0.014719331
Score:  0.239
Data Source:  BioPlex,STRINGDB
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.981536764
p_ni:  0.018463236
Score:  0.311
Data Source:  BioPlex,STRINGDB
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.974066724
p_ni:  0.02593116
p_wrong:  0.000002116
Score:  0.205
Data Source:  BioPlex,STRINGDB
GIMAP2
Tbio
Family:  Enzyme
Novelty:  0.05969307
p_int:  0.941098699
p_ni:  0.058901301
Score:  0.519
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.924053893
p_ni:  0.075946107
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.905643359
p_ni:  0.094356613
p_wrong:  2.8e-8
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.875658056
p_ni:  0.124341944
Score:  0.56
Data Source:  BioPlex,STRINGDB
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.751139057
p_ni:  0.248860941
p_wrong:  2e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  161.39

PubMed score by year
PubTator Score  61.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer