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Tbio
IRS4
Insulin receptor substrate 4

Protein Summary
Description
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372129
  • ENSP00000361202
  • ENSG00000133124

Symbol
  • IRS-4
  • PY160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
0.99
PubMedID
0.64
histone modification site profile
0.58
microRNA
0.54


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.21   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.21   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1338009
16370
Dog
insulin receptor substrate 4
VGNC:42100
492059
Horse
insulin receptor substrate 4
VGNC:19142
100059954
Cow
insulin receptor substrate 4
VGNC:30285
514607
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
insulin receptor substrate 4
Horse
insulin receptor substrate 4
Cow
insulin receptor substrate 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14654-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (36)
IGF1R signaling cascade (R-HSA-2428924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IGF1R signaling cascade
Reactome
IRS-related events triggered by IGF1R
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Name
Explore in Pharos
Explore in Source
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Protein-Protein Interactions (72)
1 – 10 of 72
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.968
Data Source:  Reactome,STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.954
Data Source:  Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.945
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.943
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.912
Data Source:  STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
Score:  0.901
Data Source:  STRINGDB
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.883
Data Source:  STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.882
Data Source:  STRINGDB
PTPN1
Tchem
Family:  Enzyme
Novelty:  0.00065779
Score:  0.874
Data Source:  STRINGDB
PIK3R5
Tbio
Family:  Enzyme
Novelty:  0.0147283
Score:  0.86
Data Source:  STRINGDB
Publication Statistics
PubMed Score  63.21

PubMed score by year
PubTator Score  43.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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