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Tbio
GOSR2
Golgi SNAP receptor complex member 2

Protein Summary
Description
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225567
  • ENSP00000225567
  • ENSG00000108433
  • ENST00000640051
  • ENSP00000492751
  • ENST00000640621
  • ENSP00000492830

Symbol
  • GS27
  • Bos1
  • EPM6
  • GS27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.91
interacting protein
0.85
disease perturbation
0.83
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.03   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.03   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
3
1
3
90.3
blood urea nitrogen measurement
2
2
2
74.8
blood pressure
1
1
1
74.1
pulse pressure measurement
1
1
1
66.9
electrocardiography
1
1
21
64.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
3
90.3
blood urea nitrogen measurement
2
74.8
blood pressure
1
74.1
pulse pressure measurement
1
66.9
electrocardiography
21
64.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi SNAP receptor complex member 2
107968983
Macaque
golgi SNAP receptor complex member 2
716841
Mouse
MGI:1927204
56494
Rat
RGD:62079
64154
Dog
golgi SNAP receptor complex member 2
610436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi SNAP receptor complex member 2
Macaque
golgi SNAP receptor complex member 2
Mouse
Rat
Dog
golgi SNAP receptor complex member 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (206)
1 – 10 of 206
STX7
Tbio
Novelty: 0.03109969
p_int: 0.99998756
p_ni: 0.000012439
Score: 0.904
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999955537
p_ni: 0.000044463
Score: 0.983
Data Source: BioPlex,STRINGDB
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.999950801
p_ni: 0.000049199
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.9999392
p_ni: 0.0000608
Data Source: BioPlex
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.999907713
p_ni: 0.000092262
p_wrong: 2.5e-8
Score: 0.668
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999881846
p_ni: 0.000118108
p_wrong: 4.6e-8
Score: 0.951
Data Source: BioPlex,STRINGDB
SEC22B
Tbio
Novelty: 0.03035448
p_int: 0.999808827
p_ni: 0.000189857
p_wrong: 0.000001316
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TRDN
Tbio
Novelty: 0.00501554
p_int: 0.994643317
p_ni: 0.005356679
p_wrong: 4e-9
Score: 0.212
Data Source: BioPlex,STRINGDB
VAMP4
Tbio
Novelty: 0.02949854
p_int: 0.99394878
p_ni: 0.006051218
p_wrong: 2e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
STX5
Tbio
Novelty: 0.00964918
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  43.03

PubMed score by year
PubTator Score  15.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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