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Tclin
KCNK3
Potassium channel subfamily K member 3

Protein Summary
Description
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302909
  • ENSP00000306275
  • ENSG00000171303

Symbol
  • TASK
  • TASK1
  • OAT1
  • PPH4
  • TASK
  • TBAK1
  • K2p3.1
  • TASK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
gene perturbation
0.81
disease perturbation
0.68
microRNA
0.68
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.91   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.91   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 522
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (522)
Ba<sup>2+</sup>
no chemical structure image available
anandamide
Rendered image for anandamide
arachidonic acid
Rendered image for arachidonic acid
CHEMBL148342
Rendered image for CHEMBL148342
S9947
Rendered image for S9947
Methanandamide
Rendered image for Methanandamide
CHEMBL1671897
Rendered image for CHEMBL1671897
US9284333, 16ci
Rendered image for US9284333, 16ci
Protein-Protein Interactions (70)
KCNK9
Tclin
Family:  IC
Novelty:  0.00587016
Score:  0.907
Data Source:  Reactome,STRINGDB
S100A10
Tbio
Novelty:  0.00281525
Score:  0.812
Data Source:  STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
Score:  0.802
Data Source:  STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
Score:  0.754
Data Source:  STRINGDB
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
Score:  0.65
Data Source:  STRINGDB
KCNV1
Tclin
Family:  IC
Novelty:  0.13544994
Score:  0.621
Data Source:  STRINGDB
KCNJ5
Tchem
Family:  IC
Novelty:  0.00385775
Score:  0.612
Data Source:  STRINGDB
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
Score:  0.59
Data Source:  STRINGDB
KCNJ3
Tchem
Family:  IC
Novelty:  0.00373765
Score:  0.583
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.581
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
5
8
89.9
triglyceride measurement
2
3
3
89.4
2
5
5
88.6
Calcium channel blocker use measurement
1
1
1
80
C-reactive protein measurement
2
2
3
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
8
89.9
triglyceride measurement
3
89.4
5
88.6
Calcium channel blocker use measurement
1
80
C-reactive protein measurement
3
80
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1100509
16527
Rat
RGD:61997
29553
Dog
potassium two pore domain channel subfamily K member 3
VGNC:42275
483002
Horse
potassium two pore domain channel subfamily K member 3
VGNC:51333
102150125
Cow
potassium two pore domain channel subfamily K member 3
VGNC:30473
519188
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 3
Horse
potassium two pore domain channel subfamily K member 3
Cow
potassium two pore domain channel subfamily K member 3
Publication Statistics
PubMed Score 342.91
PubMed score by year
PubTator Score 401.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text