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Tbio
CHD1
Chromodomain-helicase-DNA-binding protein 1

Protein Summary
Description
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). The CHD family of pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284049
  • ENSP00000284049
  • ENSG00000153922
  • ENST00000614616
  • ENSP00000483667

Symbol
  • CHD-1
  • PILBOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
molecular function
0.99
protein domain
0.99
disease perturbation
0.9
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.95   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.95   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
34.9
eosinophil percentage of granulocytes
1
1
1
34.9
1
1
0
1.7
34.3
1
1
0
1.7
34.3
neutrophil percentage of granulocytes
1
1
1
30.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
34.9
eosinophil percentage of granulocytes
1
34.9
0
1.7
34.3
0
1.7
34.3
neutrophil percentage of granulocytes
1
30.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 1
VGNC:3950
461968
Macaque
chromodomain helicase DNA binding protein 1
702070
Mouse
MGI:88393
12648
Rat
RGD:1306794
308215
Dog
chromodomain helicase DNA binding protein 1
VGNC:39199
488891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain helicase DNA binding protein 1
Macaque
chromodomain helicase DNA binding protein 1
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14646-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (244)
1 – 10 of 244
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
Score: 0.986
Data Source: STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.981
Data Source: STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
Score: 0.968
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.965
Data Source: STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.962
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.954
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.943
Data Source: STRINGDB
PAF1
Tbio
Family: Enzyme
Novelty: 0.00200047
Score: 0.939
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.935
Data Source: STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  212.95

PubMed score by year
PubTator Score  82.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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