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Tbio
DNALI1
Axonemal dynein light intermediate polypeptide 1

Protein Summary
Description
May play a dynamic role in flagellar motility. This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296218
  • ENSP00000296218
  • ENSG00000163879

Symbol
  • P28
  • hp28
  • dJ423B22.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
tissue sample
0.57
gene perturbation
0.56
tissue
0.53
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
64
intraocular pressure measurement
1
2
2
42.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
64
intraocular pressure measurement
2
42.8
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (99)
1 – 10 of 99
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.96
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.957
Data Source: STRINGDB
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.909
Data Source: STRINGDB
DNAAF1
Tbio
Novelty: 0.03962936
Score: 0.904
Data Source: STRINGDB
DNAH9
Tdark
Novelty: 0.04634487
Score: 0.899
Data Source: STRINGDB
DNAL1
Tbio
Novelty: 0.00168166
Score: 0.895
Data Source: STRINGDB
DNAH6
Tdark
Novelty: 0.18343511
Score: 0.884
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.881
Data Source: STRINGDB
TCTE3
Tdark
Novelty: 0.15747856
Score: 0.871
Data Source: STRINGDB
DNAH7
Tbio
Novelty: 0.13519686
Score: 0.856
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.19

PubMed score by year
PubTator Score  5.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer