Tbio DNALI1 Axonemal dynein light intermediate polypeptide 1

Protein Summary

Description

May play a dynamic role in flagellar motility. This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14645
• A8K387
• B4DHN6
• Q05BL9
• Q5HYE2
• Q5TGH0
• Q7L0I5

Gene Name

• DNALI1

Ensembl ID

• ENST00000296218
• ENSP00000296218
• ENSG00000163879

Symbol

• P28
• hp28
• dJ423B22.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.67
tissue sample	0.57
gene perturbation	0.56
tissue	0.53
cell line	0.52

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Axonemal Dynein Light Intermediate Polypeptide 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Axonemal Dynein Light Intermediate Polypeptide 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0