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Tbio
DVL2
Segment polarity protein dishevelled homolog DVL-2

Protein Classes
PANTHER Classes Protein / Signaling Molecule / Segment Polarity Protein Dishevelled Homolog Dvl-2 Protein / Enzyme Modulator / Segment Polarity Protein Dishevelled Homolog Dvl-2
DTO ClassesProtein / Signaling / Segment Polarity Protein Dishevelled Homolog Dvl-2
Protein Summary
Description
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005340
  • ENSP00000005340
  • ENSG00000004975
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.97
hub protein
0.97
transcription factor binding site profile
0.92
virus perturbation
0.72


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: < 5)
View Publications
Gene RIFs: 53   (req: <= 3)
View Gene RIFs
Antibodies: 423   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
EFO_0004725
1
1
1
47.3
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
EFO_0004725
1
47.3
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (58)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
65 targets
R-HSA-4608870
Reactome
Beta-catenin independent WNT signaling
146 targets
R-HSA-3858494
Reactome
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Reactome
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Reactome
Degradation of DVL
58 targets
R-HSA-4641258
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
65 targets
R-HSA-4608870
Beta-catenin independent WNT signaling
146 targets
R-HSA-3858494
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Degradation of DVL
58 targets
R-HSA-4641258
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
frizzled binding
Inferred from Physical Interaction (IPI)
UniProtKB
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
protein binding, bridging
Inferred from Electronic Annotation (IEA)
Ensembl
protein domain specific binding
Inferred from Electronic Annotation (IEA)
Ensembl
protein kinase binding
Inferred from Electronic Annotation (IEA)
Ensembl
protein self-association
Inferred from Electronic Annotation (IEA)
Ensembl
Rac GTPase binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (388)
1 – 10 of 388
DVL3
Tbio
Novelty: 0.01606014
p_int: 0.999999401
p_ni: 4.63e-7
p_wrong: 1.36e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999999234
p_ni: 5.82e-7
p_wrong: 1.84e-7
Data Source: BioPlex
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999980547
p_ni: 0.000019453
Score: 0.255
Data Source: BioPlex,STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.00335243
p_int: 0.999909904
p_ni: 0.000090095
p_wrong: 1e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.999615176
p_ni: 0.000384824
Score: 0.977
Data Source: BioPlex,STRINGDB
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.99932598
p_ni: 0.00067402
Score: 0.239
Data Source: BioPlex,STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
p_int: 0.999286752
p_ni: 0.000713247
p_wrong: 1e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
p_int: 0.999160969
p_ni: 0.000179164
p_wrong: 0.000659867
Score: 0.965
Data Source: BioPlex,STRINGDB
LRRC4C
Tbio
Novelty: 0.06534005
p_int: 0.998771303
p_ni: 0.001228697
p_wrong: 1e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
OLFM2
Tbio
Novelty: 0.06929963
p_int: 0.997038219
p_ni: 0.002423926
p_wrong: 0.000537855
Data Source: BioPlex
Publication Statistics
PubMed Score  111.83

PubMed score by year
PubTator Score  60.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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