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Tbio
DVL2
Segment polarity protein dishevelled homolog DVL-2

Protein Classes
Protein Summary
Description
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005340
  • ENSP00000005340
  • ENSG00000004975
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.97
hub protein
0.97
transcription factor binding site profile
0.92
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.83   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
47.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
47.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dishevelled segment polarity protein 2
VGNC:9267
455236
Mouse
MGI:106613
13543
Rat
RGD:1309725
303251
Dog
dishevelled segment polarity protein 2
VGNC:40138
489464
Horse
dishevelled segment polarity protein 2
VGNC:17362
100061612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dishevelled segment polarity protein 2
Mouse
Rat
Dog
dishevelled segment polarity protein 2
Horse
dishevelled segment polarity protein 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14641-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Degradation of DVL
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Degradation of DVL
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (388)
1 – 10 of 388
DVL3
Tbio
Novelty: 0.01606014
p_int: 0.999999401
p_ni: 4.63e-7
p_wrong: 1.36e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999999234
p_ni: 5.82e-7
p_wrong: 1.84e-7
Data Source: BioPlex
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999980547
p_ni: 0.000019453
Score: 0.255
Data Source: BioPlex,STRINGDB
WWOX
Tbio
Family: Enzyme
Novelty: 0.00335243
p_int: 0.999909904
p_ni: 0.000090095
p_wrong: 1e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.999615176
p_ni: 0.000384824
Score: 0.977
Data Source: BioPlex,STRINGDB
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.99932598
p_ni: 0.00067402
Score: 0.239
Data Source: BioPlex,STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
p_int: 0.999286752
p_ni: 0.000713247
p_wrong: 1e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
p_int: 0.999160969
p_ni: 0.000179164
p_wrong: 0.000659867
Score: 0.965
Data Source: BioPlex,STRINGDB
LRRC4C
Tbio
Novelty: 0.06534005
p_int: 0.998771303
p_ni: 0.001228697
p_wrong: 1e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
OLFM2
Tbio
Novelty: 0.06929963
p_int: 0.997038219
p_ni: 0.002423926
p_wrong: 0.000537855
Data Source: BioPlex
Publication Statistics
PubMed Score  111.83

PubMed score by year
PubTator Score  60.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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