DVL2
Segment polarity protein dishevelled homolog DVL-2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological process | 0.97 | ||
hub protein | 0.97 | ||
transcription factor binding site profile | 0.92 | ||
virus perturbation | 0.72 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Degradation of DVL | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Degradation of DVL | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 4 | 7 | 6 | 15.8 | 99.5 | ||||
apolipoprotein B measurement | 2 | 6 | 7 | 97.8 | |||||
low density lipoprotein cholesterol measurement | 7 | 5 | 12 | 97.1 | |||||
total cholesterol measurement | 4 | 4 | 8 | 95.8 | |||||
birth weight | 4 | 3 | 4 | 89.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 6 | 15.8 | 99.5 | ||||
apolipoprotein B measurement | 7 | 97.8 | |||||
low density lipoprotein cholesterol measurement | 12 | 97.1 | |||||
total cholesterol measurement | 8 | 95.8 | |||||
birth weight | 4 | 89.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dishevelled segment polarity protein 2 | VGNC:9267 | 455236 | |||||
Mouse | MGI:106613 | 13543 | ||||||
Rat | RGD:1309725 | 303251 | ||||||
Dog | dishevelled segment polarity protein 2 | VGNC:40138 | 489464 | |||||
Horse | dishevelled segment polarity protein 2 | VGNC:17362 | 100061612 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dishevelled segment polarity protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dishevelled segment polarity protein 2 | |||||
Horse | dishevelled segment polarity protein 2 | |||||
PMID | Year | Title |
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