Tbio DVL2 Segment polarity protein dishevelled homolog DVL-2

Protein Summary

Description

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14641
• D3DTN3
• Q53XM0
• Dishevelled-2

Gene Name

• DVL2

Ensembl ID

• ENST00000005340
• ENSP00000005340
• ENSG00000004975

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.97
hub protein	0.97
transcription factor binding site profile	0.92
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Segment Polarity Protein Dishevelled Homolog Dvl-2

Protein / Enzyme Modulator / Segment Polarity Protein Dishevelled Homolog Dvl-2

DTO Classes

Protein / Signaling / Segment Polarity Protein Dishevelled Homolog Dvl-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.56   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 423   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.56   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (388)

Explore Interacting Targets

1 – 10 of 388

• See Interactions on String-DB

DVL3

Tbio

Novelty:  0.01606014

p_int:  0.999999401

p_ni:  4.63e-7

p_wrong:  1.36e-7

Score:  0.965

Data Source:  BioPlex,STRINGDB

NXF2

Tbio

Novelty:  0.04733504

p_int:  0.999999234

p_ni:  5.82e-7

p_wrong:  1.84e-7

Data Source:  BioPlex

FOXK2

Tbio

Family:  TF

Novelty:  0.01420141

p_int:  0.999980547

p_ni:  0.000019453

Score:  0.255

Data Source:  BioPlex,STRINGDB

WWOX

Tbio

Family:  Enzyme

Novelty:  0.00335243

p_int:  0.999909904

p_ni:  0.000090095

p_wrong:  1e-9

Score:  0.689

Data Source:  BioPlex,STRINGDB

VANGL1

Tbio

Novelty:  0.00968008

p_int:  0.999615176

p_ni:  0.000384824

Score:  0.977

Data Source:  BioPlex,STRINGDB

FOXK1

Tbio

Family:  TF

Novelty:  0.01321144

p_int:  0.99932598

p_ni:  0.00067402

Score:  0.239

Data Source:  BioPlex,STRINGDB

VANGL2

Tbio

Novelty:  0.00529796

p_int:  0.999286752

p_ni:  0.000713247

p_wrong:  1e-9

Score:  0.971

Data Source:  BioPlex,STRINGDB

DVL1

Tchem

Novelty:  0.00356876

p_int:  0.999160969

p_ni:  0.000179164

p_wrong:  0.000659867

Score:  0.965

Data Source:  BioPlex,STRINGDB

LRRC4C

Tbio

Novelty:  0.06534005

p_int:  0.998771303

p_ni:  0.001228697

p_wrong:  1e-9

Score:  0.16

Data Source:  BioPlex,STRINGDB

OLFM2

Tbio

Novelty:  0.06929963

p_int:  0.997038219

p_ni:  0.002423926

p_wrong:  0.000537855

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (1)

1 – 2 of 2

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  12

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  8 more common pathways

EDNRB

Tclin

Family:  GPCR

KEGG Distance:  2

Common Pathways:  2

1: Pathways in cancer

2: Melanogenesis

Pathways (58)

Reactome (19)

KEGG (13)

PathwayCommons (13)

WikiPathways (13)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Degradation of DVL	58 targets	R-HSA-4641258

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Degradation of DVL	58 targets	R-HSA-4641258

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (42)

Functions (7)

Components (10)

Processes (25)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
frizzled binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein binding, bridging	Inferred from Electronic Annotation (IEA)	Ensembl
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein self-association	Inferred from Electronic Annotation (IEA)	Ensembl
Rac GTPase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (35)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 35

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	7	6	15.8	99.5
apolipoprotein B measurement	EFO_0004615	2	6	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	7	5	12		97.1
total cholesterol measurement	EFO_0004574	4	4	8		95.8
birth weight	EFO_0004344	4	3	4		89.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 35

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	6	15.8	99.5
apolipoprotein B measurement	EFO_0004615	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	12		97.1
total cholesterol measurement	EFO_0004574	8		95.8
birth weight	EFO_0004344	4		89.4

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UniProt Keyword Find Similar Targets

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3D-structure
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Developmental protein
Membrane
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

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alkaline phosphatase measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
birth weight
body height at birth
C-reactive protein measurement
diastolic blood pressure
Diuretic use measurement
eosinophil count
eosinophil percentage of leukocytes

MGI Phenotype Find Similar Targets

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cardiovascular system phenotype
embryo phenotype
homeostasis/metabolism phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dishevelled segment polarity protein 2	VGNC:9267	455236
Mouse	dishevelled segment polarity protein 2	MGI:106613	13543
Rat	dishevelled segment polarity protein 2	RGD:1309725	303251
Dog	dishevelled segment polarity protein 2	VGNC:40138	489464
Horse	dishevelled segment polarity protein 2	VGNC:17362	100061612

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dishevelled segment polarity protein 2
Mouse	dishevelled segment polarity protein 2
Rat	dishevelled segment polarity protein 2
Dog	dishevelled segment polarity protein 2
Horse	dishevelled segment polarity protein 2

Publication Statistics

PubMed Score 117.56

PubMed score by year

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PubTator Score 60.87

PubTator score by year

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Related Publications

Text Mined References (94)

GeneRif Annotations (53)

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PMID	Year	Title