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Tchem
DVL1
Segment polarity protein dishevelled homolog DVL-1

Protein Classes
Protein Summary
Description
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378888
  • ENSP00000368166
  • ENSG00000107404
  • ENST00000378891
  • ENSP00000368169

Symbol
  • DVL
  • DRS2
  • DVL1L1
  • DVL1P1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
hub protein
0.82
pathway
0.7
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.6   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.6   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3814692
chemical structure image
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dishevelled segment polarity protein 1
VGNC:10606
457191
Mouse
MGI:94941
13542
Rat
RGD:620632
83721
Dog
dishevelled segment polarity protein 1
VGNC:53355
100855811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dishevelled segment polarity protein 1
Mouse
Rat
Dog
dishevelled segment polarity protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14640-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (147)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Degradation of DVL
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
PCP/CE pathway
Gene Ontology Terms (60)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (282)
1 – 10 of 282
ZNF74
Tbio
Family: TF
Novelty: 0.10554307
p_int: 0.999417199
p_ni: 3.6e-8
p_wrong: 0.000582765
Data Source: BioPlex
DVL2
Tbio
Novelty: 0.00833084
p_int: 0.999160969
p_ni: 0.000179164
p_wrong: 0.000659867
Score: 0.965
Data Source: BioPlex,STRINGDB
AXIN1
Tbio
Novelty: 0.00175842
Score: 0.996
Data Source: Reactome,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.992
Data Source: STRINGDB
NKD2
Tbio
Novelty: 0.04042015
Score: 0.992
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.989
Data Source: Reactome,STRINGDB
WNT5A
Tbio
Novelty: 0.00125563
Score: 0.987
Data Source: STRINGDB
NKD1
Tbio
Novelty: 0.01491231
Score: 0.986
Data Source: STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
Score: 0.986
Data Source: STRINGDB
DAAM1
Tbio
Novelty: 0.02143008
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  280.60

PubMed score by year
PubTator Score  69.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer