Tchem DVL1 Segment polarity protein dishevelled homolog DVL-1

Protein Summary

Description

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14640
• Q5TA33
• Q5TA35
• Dishevelled-1

Gene Name

• DVL1

Ensembl ID

• ENST00000378888
• ENSP00000368166
• ENSG00000107404
• ENST00000378891
• ENSP00000368169

Symbol

• DVL
• DRS2
• DVL1L1
• DVL1P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
protein domain	1
hub protein	0.82
pathway	0.7
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Segment Polarity Protein Dishevelled Homolog Dvl-1

Protein / Enzyme Modulator / Segment Polarity Protein Dishevelled Homolog Dvl-1

DTO Classes

Protein / Signaling / Segment Polarity Protein Dishevelled Homolog Dvl-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.43   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.43   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0