Tchem ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Protein Summary

Description

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463). The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• O14638
• Q5JTL3
• E-NPP 3

Gene Name

• ENPP3

Ensembl ID

• ENST00000357639
• ENSP00000350265
• ENSG00000154269
• ENST00000414305
• ENSP00000406261

Symbol

• PDNP3
• B10
• NPP3
• PDNP3
• CD203c
• PD-IBETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
cell type or tissue	0.92
molecular function	0.91
kinase perturbation	0.81
PubMedID	0.81

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pyrophosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 3

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 3

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.96   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 445   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.96   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0