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Tbio
CCS
Copper chaperone for superoxide dismutase

Protein Summary
Description
Delivers copper to copper zinc superoxide dismutase (SOD1). Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000533244
  • ENSP00000436318
  • ENSG00000173992
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.85
tissue sample
0.64
cell line
0.61
cell type or tissue
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.9   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.9   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SCRN2
Tdark
Family:  Enzyme
Novelty:  1.63547022
p_int:  0.999823876
p_ni:  0.000176096
p_wrong:  2.8e-8
Score:  0.325
Data Source:  BioPlex,STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
p_int:  0.999757702
p_ni:  0.000242298
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.998165239
p_ni:  0.001834309
p_wrong:  4.52e-7
Data Source:  BioPlex
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.987051776
p_ni:  0.012539705
p_wrong:  0.000408519
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATOX1
Tbio
Novelty:  0.00509938
Score:  0.979
Data Source:  STRINGDB
PPIL3
Tbio
Family:  Enzyme
Novelty:  0.09773948
Score:  0.882
Data Source:  STRINGDB
RAE1
Tbio
Novelty:  0.01342883
Score:  0.863
Data Source:  STRINGDB
COX17
Tbio
Family:  Enzyme
Novelty:  0.01025112
Score:  0.847
Data Source:  STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.824
Data Source:  STRINGDB
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
Score:  0.82
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
65.7
apolipoprotein B measurement
2
2
2
65.7
insomnia measurement
1
2
0
1.1
57.1
major depressive disorder
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
65.7
apolipoprotein B measurement
2
65.7
insomnia measurement
0
1.1
57.1
major depressive disorder
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copper chaperone for superoxide dismutase
VGNC:3159
451348
Macaque
copper chaperone for superoxide dismutase
721802
Mouse
MGI:1333783
12460
Rat
RGD:620403
84485
Dog
copper chaperone for superoxide dismutase
VGNC:38919
442988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copper chaperone for superoxide dismutase
Macaque
copper chaperone for superoxide dismutase
Mouse
Rat
Dog
copper chaperone for superoxide dismutase
Publication Statistics
PubMed Score 59.90
PubMed score by year
PubTator Score 60.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title