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Tbio
CCS
Copper chaperone for superoxide dismutase

Protein Classes
Protein Summary
Description
Delivers copper to copper zinc superoxide dismutase (SOD1). Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000533244
  • ENSP00000436318
  • ENSG00000173992
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.85
tissue sample
0.64
cell line
0.61
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (57)
1 – 10 of 57
SCRN2
Tdark
Family: Enzyme
p_int: 0.999823876
p_ni: 0.000176096
p_wrong: 2.8e-8
Score: 0.325
Data Source: BioPlex,STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00044941
p_int: 0.999757702
p_ni: 0.000242298
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
DNAL4
Tdark
Novelty: 0.2970297
p_int: 0.998165239
p_ni: 0.001834309
p_wrong: 4.52e-7
Data Source: BioPlex
CAPZA2
Tdark
Novelty: 0.27435063
p_int: 0.987051776
p_ni: 0.012539705
p_wrong: 0.000408519
Score: 0.185
Data Source: BioPlex,STRINGDB
ATOX1
Tbio
Novelty: 0.00696603
Score: 0.979
Data Source: STRINGDB
PPIL3
Tbio
Family: Enzyme
Novelty: 0.12295082
Score: 0.882
Data Source: STRINGDB
RAE1
Tbio
Novelty: 0.01512278
Score: 0.863
Data Source: STRINGDB
COX17
Tbio
Family: Enzyme
Novelty: 0.01613975
Score: 0.847
Data Source: STRINGDB
SOD3
Tbio
Family: Enzyme
Novelty: 0.00191811
Score: 0.824
Data Source: STRINGDB
ATP7A
Tbio
Family: Enzyme
Novelty: 0.00077444
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.03

PubMed score by year
PubTator Score  60.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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