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Tbio
AP3D1
AP-3 complex subunit delta-1

Protein Summary
Description
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense gra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345016
  • ENSP00000344055
  • ENSG00000065000
  • ENST00000355272
  • ENSP00000347416
  • ENST00000643116
  • ENSP00000495274

Symbol
  • ADTD
  • HPS10
  • hBLVR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
drug perturbation
0.96
disease perturbation
0.87
virus perturbation
0.83
cellular component
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.38   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.38   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.99999954
p_ni:  4.6e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
AP3M1
Tbio
Novelty:  0.5036622
p_int:  0.999997498
p_ni:  0.000002502
Score:  0.999
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.9999702
p_ni:  0.0000298
Data Source:  BioPlex
RNF13
Tbio
Family:  Enzyme
Novelty:  0.09764564
p_int:  0.998617223
p_ni:  0.001382777
Score:  0.534
Data Source:  BioPlex,STRINGDB
AP3M2
Tbio
Novelty:  0.18164255
p_int:  0.994317857
p_ni:  0.005682143
Score:  0.994
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.980723892
p_ni:  0.019276108
Score:  0.249
Data Source:  BioPlex,STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.975524326
p_ni:  0.024475671
p_wrong:  3e-9
Score:  0.545
Data Source:  BioPlex,STRINGDB
AGO3
Tbio
Novelty:  0.01664154
p_int:  0.970227832
p_ni:  0.029772168
Score:  0.829
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.963526731
p_ni:  0.036473269
Score:  0.41
Data Source:  BioPlex,STRINGDB
AP3B1
Tbio
Novelty:  0.03117931
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
6
6
98
hemoglobin measurement
5
5
5
97.7
BMI-adjusted hip circumference
3
13
15
96.3
body height
5
5
5
94
red blood cell density measurement
2
2
2
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
98
hemoglobin measurement
5
97.7
BMI-adjusted hip circumference
15
96.3
body height
5
94
red blood cell density measurement
2
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit delta 1
VGNC:6613
455565
Macaque
adaptor related protein complex 3 delta 1 subunit
100430853
Mouse
MGI:107734
11776
Rat
RGD:1308659
314633
Dog
adaptor related protein complex 3 subunit delta 1
VGNC:37965
476750
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit delta 1
Macaque
adaptor related protein complex 3 delta 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 3 subunit delta 1
Publication Statistics
PubMed Score 21.38
PubMed score by year
PubTator Score 7.02
PubTator score by year
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Related Publications
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PMID
Year
Title