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Tbio
CDC42EP2
Cdc42 effector protein 2

Protein Summary
Description
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279249
  • ENSP00000279249
  • ENSG00000149798
  • ENST00000533419
  • ENSP00000431660

Symbol
  • BORG1
  • CEP2
  • CEP2
  • BORG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
cell type or tissue
0.67
tissue sample
0.66
gene perturbation
0.65
small molecule perturbation
0.61


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CDC42 effector protein 2
716504
Mouse
MGI:1929744
104252
Rat
RGD:1310253
309175
Dog
CDC42 effector protein 2
VGNC:39001
483744
Horse
CDC42 effector protein 2
VGNC:16298
100056801
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CDC42 effector protein 2
Mouse
Rat
Dog
CDC42 effector protein 2
Horse
CDC42 effector protein 2
Pathways (3)
MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Signal Transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (45)
1 – 10 of 45
CDC42EP5
Tbio
Novelty: 0.10102479
Score: 0.99
Data Source: STRINGDB
SEPT7
Tbio
Novelty: 0.00554708
Score: 0.957
Data Source: Reactome,STRINGDB
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
Score: 0.922
Data Source: Reactome,STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
Score: 0.912
Data Source: Reactome,STRINGDB
CDC42EP3
Tbio
Novelty: 0.00908722
Score: 0.91
Data Source: STRINGDB
SSSCA1
Tdark
Novelty: 0.53523038
Score: 0.755
Data Source: STRINGDB
FAM89B
Tbio
Novelty: 0.10306021
Score: 0.754
Data Source: STRINGDB
ARHGAP26
Tbio
Family: Enzyme
Novelty: 0.02409941
Score: 0.723
Data Source: STRINGDB
TIGD3
Tdark
Novelty: 1.23642174
Score: 0.71
Data Source: STRINGDB
FRMD8
Tdark
Novelty: 0.39375892
Score: 0.693
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.31

PubMed score by year
PubTator Score  3.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer