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Tbio
GNGT2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300406
  • ENSP00000300406
  • ENSG00000167083
  • ENST00000507680
  • ENSP00000421710
  • ENST00000511277
  • ENSP00000426022
  • ENST00000511673
  • ENSP00000422879
  • ENST00000515635
  • ENSP00000423924

Symbol
  • GNG8
  • GNG9
  • GNGT8
  • GNG8
  • GNG9
  • GNGT8
  • G-GAMMA-8
  • G-GAMMA-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
transcription factor
0.63
pathway
0.62
gene perturbation
0.55
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (562)
GNB4
Tbio
Novelty:  0.08250797
Score:  0.999
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.999
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.999
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.999
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.977
Data Source:  STRINGDB
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.972
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.971
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.969
Data Source:  STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
Score:  0.963
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (138)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Items per page:
1 – 5 of 58
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
3
3
6.3
94.8
sex hormone-binding globulin measurement
8
2
7
26.3
93.5
testosterone measurement
2
2
2
91.7
2
1
0
1.1
71.7
triglyceride measurement
2
2
2
63.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
6.3
94.8
sex hormone-binding globulin measurement
7
26.3
93.5
testosterone measurement
2
91.7
0
1.1
71.7
triglyceride measurement
2
63.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma transducin 2
VGNC:9305
749133
Mouse
MGI:893584
14710
Rat
RGD:1591007
690825
Dog
G protein subunit gamma transducin 2
VGNC:41325
403617
Horse
G protein subunit gamma transducin 2
VGNC:18438
100069660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma transducin 2
Mouse
Rat
Dog
G protein subunit gamma transducin 2
Horse
G protein subunit gamma transducin 2
Publication Statistics
PubMed Score 28.66
PubMed score by year
PubTator Score 6.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title