GNGT2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
- ENST00000300406
- ENSP00000300406
- ENSG00000167083
- ENST00000507680
- ENSP00000421710
- ENST00000511277
- ENSP00000426022
- ENST00000511673
- ENSP00000422879
- ENST00000515635
- ENSP00000423924
- GNG8
- GNG9
- GNGT8
- GNG8
- GNG9
- GNGT8
- G-GAMMA-8
- G-GAMMA-C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.69 | ||
transcription factor | 0.63 | ||
pathway | 0.62 | ||
gene perturbation | 0.55 | ||
cell line | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.66 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.66 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0