UTY
Histone demethylase UTY
Protein Summary
Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]
- ENST00000329134
- ENSP00000330446
- ENSG00000183878
- ENST00000331397
- ENSP00000328939
- ENST00000362096
- ENSP00000355420
- ENST00000382896
- ENSP00000372352
- ENST00000624098
- ENSP00000485539
- KDM6C
- UTY1
- KDM6C
- KDM6AL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
microRNA | 0.78 | ||
cell type or tissue | 0.57 | ||
transcription factor | 0.54 | ||
tissue sample | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 144 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 144 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0