Tbio CTDSP2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Protein Summary

Description

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Uniprot Accession IDs

• O14595
• A8K5H4
• Q53ZR2
• Q6NZY3
• Q9UEX1

Gene Name

• CTDSP2

Ensembl ID

• ENST00000398073
• ENSP00000381148
• ENSG00000175215

Symbol

• NIF2
• OS4
• SCP2
• OS4
• PSR2
• SCP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.99
virus perturbation	0.99
transcription factor perturbation	0.96
microRNA	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.52   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.52   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0