Tbio NCAN Neurocan core protein

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Neurocan Core Protein

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Neurocan Core Protein

Protein Summary

Description

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• O14594
• Q9UPK6

Gene Name

• NCAN

Ensembl ID

• ENST00000252575
• ENSP00000252575
• ENSG00000130287

Symbol

• CSPG3
• NEUR
• CSPG3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.76
cell type or tissue	0.62
microRNA	0.6
biological process	0.57

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.91   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.91   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bipolar disorder	EFO_0000289	2	2	0	1.1	79.6
triglyceride measurement	EFO_0004530	2	1	3		79.3
total cholesterol measurement	EFO_0004574	3	1	2	3.9	75.6
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		35.4
bipolar I disorder	EFO_0009963	1	1	0	1.1	28.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bipolar disorder	EFO_0000289	0	1.1	79.6
triglyceride measurement	EFO_0004530	3		79.3
total cholesterol measurement	EFO_0004574	2	3.9	75.6
low density lipoprotein cholesterol measurement	EFO_0004611	1		35.4
bipolar I disorder	EFO_0009963	0	1.1	28.6

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Pathways (28)

Reactome (25)

PathwayCommons (2)

WikiPathways (1)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	CS/DS degradation	14 targets	R-HSA-2024101
Reactome	Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Axon guidance	533 targets	R-HSA-422475
CS/DS degradation	14 targets	R-HSA-2024101
Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185

Gene Ontology Terms (13)

Functions (3)

Components (4)

Processes (6)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
carbohydrate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
hyaluronic acid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

CSPG5

Tbio

Novelty: 0.01629685

Score: 0.969

Data Source: STRINGDB

CSPG4

Tbio

Novelty: 0.0038499

Score: 0.968

Data Source: STRINGDB

L1CAM

Tbio

Novelty: 0.00307041

Score: 0.966

Data Source: Reactome,STRINGDB

NCAM1

Tbio

Novelty: 0.00020994

Score: 0.963

Data Source: Reactome,STRINGDB

AGRN

Tbio

Novelty: 0.00156441

Score: 0.953

Data Source: STRINGDB

DCN

Tbio

Novelty: 0.00073027

Score: 0.953

Data Source: STRINGDB

CHPF

Tbio

Family: Enzyme

Novelty: 0.02590604

Score: 0.95

Data Source: STRINGDB

GPC2

Tbio

Novelty: 0.02182363

Score: 0.947

Data Source: STRINGDB

GPC1

Tbio

Novelty: 0.00293087

Score: 0.946

Data Source: STRINGDB

BCAN

Tbio

Novelty: 0.00737982

Score: 0.945

Data Source: STRINGDB

Publication Statistics

PubMed Score  247.91

PubMed score by year

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PubTator Score  24.55

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hyaluronic acid
Immunoglobulin domain
Lectin
Polymorphism

GWAS Trait Find Similar Targets

bipolar disorder
bipolar I disorder
low density lipoprotein cholesterol measurement
total cholesterol measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

nervous system phenotype