Tbio NCAN Neurocan core protein

Protein Summary

Description

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• O14594
• Q9UPK6

Gene Name

• NCAN

Ensembl ID

• ENST00000252575
• ENSP00000252575
• ENSG00000130287

Symbol

• CSPG3
• NEUR
• CSPG3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.76
cell type or tissue	0.62
microRNA	0.6
biological process	0.57

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Neurocan Core Protein

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Neurocan Core Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.22   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.22   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0