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Tbio
NCAN
Neurocan core protein

Protein Summary
Description
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252575
  • ENSP00000252575
  • ENSG00000130287

Symbol
  • CSPG3
  • NEUR
  • CSPG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.76
cell type or tissue
0.62
microRNA
0.6
biological process
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.91   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.91   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
79.6
triglyceride measurement
2
1
3
79.3
total cholesterol measurement
3
1
2
3.9
75.6
low density lipoprotein cholesterol measurement
1
1
1
35.4
bipolar I disorder
1
1
0
1.1
28.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.6
triglyceride measurement
3
79.3
total cholesterol measurement
2
3.9
75.6
low density lipoprotein cholesterol measurement
1
35.4
bipolar I disorder
0
1.1
28.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurocan
VGNC:2306
468775
Mouse
MGI:104694
13004
Rat
RGD:619941
58982
Dog
neurocan
VGNC:43638
484808
Horse
neurocan [Source:HGNC Symbol;Acc:HGNC:2465]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurocan
Mouse
Rat
Dog
neurocan
Horse
neurocan [Source:HGNC Symbol;Acc:HGNC:2465]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14594-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Axon guidance
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Axon guidance
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (154)
1 – 10 of 154
CSPG5
Tbio
Novelty: 0.01629685
Score: 0.969
Data Source: STRINGDB
CSPG4
Tbio
Novelty: 0.0038499
Score: 0.968
Data Source: STRINGDB
L1CAM
Tbio
Novelty: 0.00307041
Score: 0.966
Data Source: Reactome,STRINGDB
NCAM1
Tbio
Novelty: 0.00020994
Score: 0.963
Data Source: Reactome,STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.953
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.953
Data Source: STRINGDB
CHPF
Tbio
Family: Enzyme
Novelty: 0.02590604
Score: 0.95
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.947
Data Source: STRINGDB
GPC1
Tbio
Novelty: 0.00293087
Score: 0.946
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  247.91

PubMed score by year
PubTator Score  24.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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