Tbio NCAN Neurocan core protein

Protein Summary

Description

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• O14594
• Q9UPK6

Gene Name

• NCAN

Ensembl ID

• ENST00000252575
• ENSP00000252575
• ENSG00000130287

Symbol

• CSPG3
• NEUR
• CSPG3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.76
cell type or tissue	0.62
microRNA	0.6
biological process	0.57

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Neurocan Core Protein

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Neurocan Core Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.79   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.79   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

CSPG5

Tbio

Novelty:  0.01629685

Score:  0.969

Data Source:  STRINGDB

CSPG4

Tbio

Novelty:  0.0038499

Score:  0.968

Data Source:  STRINGDB

L1CAM

Tbio

Novelty:  0.00307041

Score:  0.966

Data Source:  Reactome,STRINGDB

NCAM1

Tbio

Novelty:  0.00020994

Score:  0.963

Data Source:  Reactome,STRINGDB

AGRN

Tbio

Novelty:  0.00156441

Score:  0.953

Data Source:  STRINGDB

DCN

Tbio

Novelty:  0.00073027

Score:  0.953

Data Source:  STRINGDB

CHPF

Tbio

Family:  Enzyme

Novelty:  0.02590604

Score:  0.95

Data Source:  STRINGDB

GPC2

Tbio

Novelty:  0.02182363

Score:  0.947

Data Source:  STRINGDB

GPC1

Tbio

Novelty:  0.00293087

Score:  0.946

Data Source:  STRINGDB

BCAN

Tbio

Novelty:  0.00737982

Score:  0.945

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (28)

Reactome (25)

PathwayCommons (2)

WikiPathways (1)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	CS/DS degradation	14 targets	R-HSA-2024101
Reactome	Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Axon guidance	533 targets	R-HSA-422475
CS/DS degradation	14 targets	R-HSA-2024101
Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (3)

Components (4)

Processes (6)

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1 – 3 of 3

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
carbohydrate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
hyaluronic acid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (44)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 44

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	14	11	20	3.8	99.8
triglyceride measurement	EFO_0004530	18	10	28	8.2	99.6
total cholesterol measurement	EFO_0004574	9	6	13	4.4	99.4
apolipoprotein B measurement	EFO_0004615	2	4	4		98.5
serum alanine aminotransferase measurement	EFO_0004735	3	4	4	17.9	98.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 44

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	20	3.8	99.8
triglyceride measurement	EFO_0004530	28	8.2	99.6
total cholesterol measurement	EFO_0004574	13	4.4	99.4
apolipoprotein B measurement	EFO_0004615	4		98.5
serum alanine aminotransferase measurement	EFO_0004735	4	17.9	98.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hyaluronic acid
Immunoglobulin domain
Lectin
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
alcoholic liver cirrhosis
alkaline phosphatase measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
bilirubin measurement
bipolar disorder
bipolar I disorder
blood metabolite measurement
BMI-adjusted waist-hip ratio
body height

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurocan	VGNC:2306	468775
Mouse	neurocan	MGI:104694	13004
Rat	neurocan	RGD:619941	58982
Dog	neurocan	VGNC:43638	484808
Horse	neurocan [Source:HGNC Symbol;Acc:HGNC:2465]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurocan
Mouse	neurocan
Rat	neurocan
Dog	neurocan
Horse	neurocan [Source:HGNC Symbol;Acc:HGNC:2465]

Publication Statistics

PubMed Score 254.79

PubMed score by year

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PubTator Score 24.55

PubTator score by year

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Related Publications

Text Mined References (39)

GeneRif Annotations (17)

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PMID	Year	Title