Tbio RFXANK DNA-binding protein RFXANK

Protein Summary

Description

Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). Isoform 2 is not involved in the positive regulation of MHC class II genes. Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O14593
• O95839
• Q24JQ1
• Q6FGA8

Gene Name

• RFXANK

Ensembl ID

• ENST00000303088
• ENSP00000305071
• ENSG00000064490
• ENST00000407360
• ENSP00000384572
• ENST00000456252
• ENSP00000409138

Symbol

• ANKRA1
• RFXB
• BLS
• RFX-B
• ANKRA1
• F14150_1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
tissue sample	0.62
cell line	0.55
biological process	0.54
interacting protein	0.54

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna-binding Protein Rfxank

DTO Classes

Protein / Transcription Factor / Dna-binding Protein Rfxank

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.51   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.51   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0