Tbio COPE Coatomer subunit epsilon

Protein Summary

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14579
• A6NE29
• A6NKA3
• O76097
• Q6IBB8
• Q9UGP6

Gene Name

• COPE

Ensembl ID

• ENST00000262812
• ENSP00000262812
• ENSG00000105669
• ENST00000349893
• ENSP00000343134
• ENST00000351079
• ENSP00000345674

Symbol

• epsilon-COP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.91
histone modification site profile	0.9
disease perturbation	0.87
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Coatomer Subunit Epsilon

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Coatomer Subunit Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.72   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.72   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0