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Tchem
CIT
Citron Rho-interacting kinase

Protein Summary
Description
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261833
  • ENSP00000261833
  • ENSG00000122966
  • ENST00000392521
  • ENSP00000376306
  • ENST00000612548
  • ENSP00000482318

Symbol
  • CRIK
  • KIAA0949
  • STK21
  • CITK
  • CRIK
  • STK21
  • MCPH17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
drug perturbation
0.96
ligand (protein) perturbation
0.96
small molecule
0.96


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
TG-100572
Rendered image for TG-100572
A-674563
Rendered image for A-674563
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
84.7
basophil count
2
2
2
78.7
myeloid white cell count
1
1
1
71.9
serum gamma-glutamyl transferase measurement
1
1
1
68
leukocyte count
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
84.7
basophil count
2
78.7
myeloid white cell count
1
71.9
serum gamma-glutamyl transferase measurement
1
68
leukocyte count
1
66.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
citron rho-interacting serine/threonine kinase
108449892
Macaque
citron rho-interacting serine/threonine kinase
695846
Mouse
MGI:105313
12704
Rat
RGD:70878
83620
Dog
citron rho-interacting serine/threonine kinase
VGNC:39282
100683247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
citron rho-interacting serine/threonine kinase
Macaque
citron rho-interacting serine/threonine kinase
Mouse
Rat
Dog
citron rho-interacting serine/threonine kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14578-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate CIT
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate CIT
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  1
Data Source:  BioPlex
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999997423
p_ni:  0.000002577
Data Source:  BioPlex
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.973984682
p_ni:  0.018833502
p_wrong:  0.007181816
Data Source:  BioPlex
KIF14
Tbio
Novelty:  0.02313641
Score:  0.993
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.979
Data Source:  Reactome,STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.972
Data Source:  Reactome,STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.954
Data Source:  Reactome,STRINGDB
PRC1
Tbio
Novelty:  0.0411653
Score:  0.947
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.946
Data Source:  Reactome,STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.946
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  25.95

PubMed score by year
PubTator Score  61.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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