Pharos : Target Details

Tchem

Protein Summary

Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000261833
ENSP00000261833
ENSG00000122966
ENST00000392521
ENSP00000376306
ENST00000612548
ENSP00000482318

Symbol

CRIK
KIAA0949
STK21
CITK
CRIK
STK21
MCPH17

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

molecular function	0.99

drug perturbation	0.96

ligand (protein) perturbation	0.96

small molecule	0.96

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95 (req: < 5)

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Gene RIFs: 27 (req: <= 3)

View Gene RIFs

Antibodies: 163 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95 (req: >= 5)

Gene RIFs: 27 (req: > 3)

Antibodies: 163 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

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Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (2)

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1 – 2 of 2

TG-100572

A-674563

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

See Interactions on String-DB

TAX1BP3

Tbio

Novelty: 0.01605171

p_int: 1

Data Source: BioPlex

BFSP1

Tbio

Novelty: 0.01519136

p_int: 0.999997423

p_ni: 0.000002577

Data Source: BioPlex

NUP62CL

Tdark

Novelty: 2.93223607

p_int: 0.973984682

p_ni: 0.018833502

p_wrong: 0.007181816

Data Source: BioPlex

KIF14

Tbio

Novelty: 0.02313641

Score: 0.993