Pharos: Illuminating the Druggable Genome

Tchem

Protein Classes

Protein Summary

Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000261833
ENSP00000261833
ENSG00000122966
ENST00000392521
ENSP00000376306
ENST00000612548
ENSP00000482318

Symbol

CRIK
KIAA0949
STK21
CITK
CRIK
STK21
MCPH17

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

molecular function	0.99

drug perturbation	0.96

ligand (protein) perturbation	0.96

small molecule	0.96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5 (req: < 5)

View Publications

Gene RIFs: 27 (req: <= 3)

View Gene RIFs

Antibodies: 163 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.5 (req: >= 5)

Gene RIFs: 27 (req: > 3)

Antibodies: 163 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

1 – 1 of 1

CHEMBL379218

Pathways (34)

Reactome (4)

PathwayCommons (1)

WikiPathways (29)

RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258

Reactome	RHO GTPases activate CIT	19 targets	R-HSA-5625900

Reactome	Signal Transduction	2704 targets	R-HSA-162582

Reactome	Signaling by Rho GTPases	402 targets	R-HSA-194315

Name	Explore in Pharos	Explore in Source
RHO GTPase Effectors	273 targets	R-HSA-195258

RHO GTPases activate CIT	19 targets	R-HSA-5625900

Signal Transduction	2704 targets	R-HSA-162582

Signaling by Rho GTPases	402 targets	R-HSA-194315

Gene Ontology Terms (22)

Functions (7)

Components (6)

Processes (9)

Items per page:

1 – 7 of 7

GO Term	Evidence	Assigned by
PDZ domain binding	Inferred from Direct Assay (IDA)	UniProtKB

scaffold protein binding	Inferred from Direct Assay (IDA)	BHF-UCL

protein serine/threonine kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Rho GTPase binding	Inferred from Electronic Annotation (IEA)	Ensembl

SH3 domain binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (63)

1 – 10 of 63

See Interactions on String-DB

TAX1BP3

Tbio

Novelty: 0.01762102

p_int: 1

Data Source: BioPlex

BFSP1

Tbio

Novelty: 0.00749498

p_int: 0.999997423

p_ni: 0.000002577

Data Source: BioPlex

NUP62CL

Tdark

p_int: 0.973984682

p_ni: 0.018833502

p_wrong: 0.007181816

Data Source: BioPlex

KIF14

Tbio

Novelty: 0.02907785

Score: 0.993