Tchem CIT Citron Rho-interacting kinase

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Dmpk Family / Citron Rho-interacting Kinase

Protein Summary

Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O14578
• Q2M5E1
• Q6XUH8
• Q86UQ9
• Q9UPZ7
• CRIK

Gene Name

• CIT

Ensembl ID

• ENST00000261833
• ENSP00000261833
• ENSG00000122966
• ENST00000392521
• ENSP00000376306
• ENST00000612548
• ENSP00000482318

Symbol

• CRIK
• KIAA0949
• STK21
• CITK
• CRIK
• STK21
• MCPH17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
drug perturbation	0.96
ligand (protein) perturbation	0.96
small molecule	0.96

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

Go To Tool

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.95   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

TG-100572

CITTchem Kinase

Kd : 8.52

A-674563

CITTchem Kinase

Kd : 7.89

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		84.7
basophil count	EFO_0005090	2	2	2		78.7
myeloid white cell count	EFO_0007988	1	1	1		71.9
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		68
leukocyte count	EFO_0004308	1	1	1		66.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		84.7
basophil count	EFO_0005090	2		78.7
myeloid white cell count	EFO_0007988	1		71.9
serum gamma-glutamyl transferase measurement	EFO_0004532	1		68
leukocyte count	EFO_0004308	1		66.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	citron rho-interacting serine/threonine kinase		108449892
Macaque	citron rho-interacting serine/threonine kinase		695846
Mouse	citron	MGI:105313	12704
Rat	citron rho-interacting serine/threonine kinase	RGD:70878	83620
Dog	citron rho-interacting serine/threonine kinase	VGNC:39282	100683247

Species	Name	OMA	EggNOG	Inparanoid
Chimp	citron rho-interacting serine/threonine kinase
Macaque	citron rho-interacting serine/threonine kinase
Mouse	citron
Rat	citron rho-interacting serine/threonine kinase
Dog	citron rho-interacting serine/threonine kinase

Protein Structure (0 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O14578-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)

Reactome (4)

PathwayCommons (1)

WikiPathways (29)

RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases activate CIT	19 targets	R-HSA-5625900
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Rho GTPases	402 targets	R-HSA-194315

Name	Explore in Pharos	Explore in Source
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases activate CIT	19 targets	R-HSA-5625900
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Rho GTPases	402 targets	R-HSA-194315

Gene Ontology Terms (22)

Functions (7)

Components (6)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
PDZ domain binding	Inferred from Direct Assay (IDA)	UniProtKB
scaffold protein binding	Inferred from Direct Assay (IDA)	BHF-UCL
protein serine/threonine kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
Rho GTPase binding	Inferred from Electronic Annotation (IEA)	Ensembl
SH3 domain binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

TAX1BP3

Tbio

Novelty:  0.01605171

p_int:  1

Data Source:  BioPlex

BFSP1

Tbio

Novelty:  0.01519136

p_int:  0.999997423

p_ni:  0.000002577

Data Source:  BioPlex

NUP62CL

Tdark

Novelty:  2.93223607

p_int:  0.973984682

p_ni:  0.018833502

p_wrong:  0.007181816

Data Source:  BioPlex

KIF14

Tbio

Novelty:  0.02313641

Score:  0.993

Data Source:  Reactome,STRINGDB

RHOA

Tbio

Family:  Enzyme

Novelty:  0.00022204

Score:  0.979

Data Source:  Reactome,STRINGDB

RHOC

Tbio

Family:  Enzyme

Novelty:  0.00262213

Score:  0.972

Data Source:  Reactome,STRINGDB

RHOB

Tbio

Family:  Enzyme

Novelty:  0.0019205

Score:  0.954

Data Source:  Reactome,STRINGDB

PRC1

Tbio

Novelty:  0.0411653

Score:  0.947

Data Source:  Reactome,STRINGDB

RAC1

Tbio

Family:  Enzyme

Novelty:  0.00365325

Score:  0.946

Data Source:  Reactome,STRINGDB

MYL9

Tbio

Novelty:  0.00309239

Score:  0.946

Data Source:  Reactome,STRINGDB

Publication Statistics

PubMed Score  25.95

PubMed score by year

Reset Zoom

PubTator Score  61.35

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
ATP-binding
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Developmental protein
Differentiation

GWAS Trait Find Similar Targets

No Header	No Header
adverse effect
basophil count
leukocyte count
lymphocyte percentage of leukocytes
mitochondrial heteroplasmy measurement
monocyte count
myeloid white cell count
neutrophil count
platelet crit
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype
reproductive system phenotype