Tclin NDUFAB1 Acyl carrier protein, mitochondrial

Protein Summary

Description

Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).

Uniprot Accession IDs

• O14561
• B2R4M1
• Q9UNV1
• ACP

Gene Name

• NDUFAB1

Ensembl ID

• ENST00000007516
• ENSP00000007516
• ENSG00000004779
• ENST00000570319
• ENSP00000458770

Symbol

• ACP
• ACP1
• SDAP
• FASN2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.97
transcription factor perturbation	0.94
virus perturbation	0.9
molecular function	0.81

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Acyl Carrier Protein, Mitochondrial

DTO Classes

Protein / Transporter / Acyl Carrier Protein, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.26   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.26   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1