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Tclin
NDUFAB1
Acyl carrier protein, mitochondrial

Protein Classes
Protein Summary
Description
Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000007516
  • ENSP00000007516
  • ENSG00000004779
  • ENST00000570319
  • ENSP00000458770

Symbol
  • ACP
  • ACP1
  • SDAP
  • FASN2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor perturbation
0.94
virus perturbation
0.9
molecular function
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit AB1
VGNC:5848
744435
Mouse
MGI:1917566
70316
Rat
RGD:1305619
293453
Dog
NADH:ubiquinone oxidoreductase subunit AB1
479805
Horse
NADH:ubiquinone oxidoreductase subunit AB1
VGNC:20628
100069079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit AB1
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit AB1
Horse
NADH:ubiquinone oxidoreductase subunit AB1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14561-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Fatty acid metabolism
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Fatty acid metabolism
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (425)
1 – 10 of 425
LYRM2
Tdark
Novelty: 0.33936166
p_int: 1
Score: 0.877
Data Source: BioPlex,STRINGDB
ETFRF1
Tdark
Novelty: 1.28847105
p_int: 0.99999996
p_ni: 4e-8
Score: 0.914
Data Source: BioPlex,STRINGDB
OXSM
Tbio
Family: Enzyme
Novelty: 0.00615894
p_int: 0.999994196
p_ni: 0.000005804
Score: 0.998
Data Source: BioPlex,STRINGDB
ATPAF2
Tbio
Family: Enzyme
Novelty: 0.04184643
p_int: 0.999975874
p_ni: 0.000024126
Score: 0.447
Data Source: BioPlex,STRINGDB
LYRM4
Tbio
Novelty: 0.03319832
p_int: 0.999966412
p_ni: 0.000004869
p_wrong: 0.000028719
Score: 0.895
Data Source: BioPlex,STRINGDB
LYRM7
Tbio
Novelty: 0.16270565
p_int: 0.999955318
p_ni: 0.000044683
Score: 0.337
Data Source: BioPlex,STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.999894205
p_ni: 0.000105795
Score: 0.803
Data Source: BioPlex,STRINGDB
SDHAF1
Tbio
Family: Enzyme
Novelty: 0.1401114
p_int: 0.99960348
p_ni: 0.00039652
Data Source: BioPlex
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.998203076
p_ni: 0.001796924
Score: 0.998
Data Source: BioPlex,STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
p_int: 0.993084947
p_ni: 0.006915053
Score: 0.369
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  466.03

PubMed score by year
PubTator Score  16.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer