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Tbio
ARHGAP33
Rho GTPase-activating protein 33

Protein Summary
Description
May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314737
  • ENSP00000320038
  • ENSG00000004777
  • ENST00000378944
  • ENSP00000368227

Symbol
  • SNX26
  • TCGAP
  • SNX26
  • TCGAP
  • NOMA-GAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor
0.67
cell type or tissue
0.63
protein domain
0.58
cell line
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.54   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.54   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 33
VGNC:11222
748029
Macaque
Rho GTPase activating protein 33
710938
Mouse
MGI:2673998
233071
Rat
RGD:2318374
100362311
Opossum
Rho GTPase activating protein 33 [Source:HGNC Symbol;Acc:HGNC:23085]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 33
Macaque
Rho GTPase activating protein 33
Mouse
Rat
Opossum
Rho GTPase activating protein 33 [Source:HGNC Symbol;Acc:HGNC:23085]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14559-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (216)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (46)
1 – 10 of 46
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.951
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.925
Data Source: STRINGDB
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
Score: 0.923
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.92
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.918
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.916
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.00734789
Score: 0.908
Data Source: STRINGDB
RHOT2
Tbio
Family: Enzyme
Novelty: 0.01712732
Score: 0.906
Data Source: STRINGDB
RHOV
Tbio
Family: Enzyme
Novelty: 0.02138482
Score: 0.905
Data Source: STRINGDB
RHOF
Tbio
Family: Enzyme
Novelty: 0.01795771
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.54

PubMed score by year
PubTator Score  2.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer