Tbio HSPB6 Heat shock protein beta-6

Protein Summary

Description

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• O14558
• O14551
• Q6NVI3
• Q96MG9
• HspB6

Gene Name

• HSPB6

Ensembl ID

• ENST00000004982
• ENSP00000004982
• ENSG00000004776

Symbol

• HEL55
• Hsp20
• PPP1R91

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
biological term	0.67
small molecule perturbation	0.61
protein domain	0.58
transcription factor	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 434.21   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 434.21   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0