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Tbio
SOCS6
Suppressor of cytokine signaling 6

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythrol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397942
  • ENSP00000381034
  • ENSG00000170677
  • ENST00000582322
  • ENSP00000463395

Symbol
  • CIS4
  • SOCS4
  • CIS4
  • SSI4
  • CIS-4
  • SOCS4
  • STAI4
  • SOCS-4
  • SOCS-6
  • STATI4
  • HSPC060
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
transcription factor perturbation
0.68
tissue sample
0.67
cell line
0.65
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.28   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.28   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (206)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999999
p_ni:  1e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999999985
p_ni:  1.4e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
ARIH2
Tbio
Family:  Enzyme
Novelty:  0.03455224
p_int:  0.999660154
p_ni:  0.000055971
p_wrong:  0.000283875
Score:  0.249
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.991778099
p_ni:  0.008221901
Score:  0.917
Data Source:  BioPlex,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
p_int:  0.975628071
p_ni:  0.024371929
Score:  0.191
Data Source:  BioPlex,STRINGDB
PLEC
Tbio
Novelty:  0.00223244
p_int:  0.887467941
p_ni:  0.112532058
Score:  0.193
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
p_int:  0.848515228
p_ni:  0.151484772
Score:  0.996
Data Source:  BioPlex,STRINGDB
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.775667268
p_ni:  0.224130296
p_wrong:  0.000202436
Score:  0.193
Data Source:  BioPlex,STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.985
Data Source:  STRINGDB
KIT
Tclin
Family:  Kinase
Novelty:  0.00011237
Score:  0.972
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (307)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Reactome
Regulation of KIT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Regulation of KIT signaling
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 6
VGNC:13290
455521
Macaque
suppressor of cytokine signaling 6
704108
Mouse
MGI:1924885
54607
Rat
RGD:1304632
307200
Dog
suppressor of cytokine signaling 6
100856303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 6
Macaque
suppressor of cytokine signaling 6
Mouse
Rat
Dog
suppressor of cytokine signaling 6
Publication Statistics
PubMed Score 102.28
PubMed score by year
PubTator Score 269.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title