Tbio SOCS6 Suppressor of cytokine signaling 6

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14544
• Q8WUM3
• SOCS-6

Gene Name

• SOCS6

Ensembl ID

• ENST00000397942
• ENSP00000381034
• ENSG00000170677
• ENST00000582322
• ENSP00000463395

Symbol

• CIS4
• SOCS4
• CIS4
• SSI4
• CIS-4
• SOCS4
• STAI4
• SOCS-4
• SOCS-6
• STATI4
• HSPC060

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.71
transcription factor perturbation	0.68
tissue sample	0.67
cell line	0.65
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 6

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.03   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.03   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0