Tbio SOCS3 Suppressor of cytokine signaling 3

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14543
• O14509
• SOCS-3

Gene Name

• SOCS3

Ensembl ID

• ENST00000330871
• ENSP00000330341
• ENSG00000184557

Symbol

• CIS3
• SSI3
• CIS3
• SSI3
• ATOD4
• Cish3
• SSI-3
• SOCS-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
virus perturbation	0.99
gene perturbation	0.98
disease perturbation	0.97
transcription factor binding site profile	0.96

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 3

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2115.22   (req: < 5)

Gene RIFs: 452   (req: <= 3)

Antibodies: 705   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2115.22   (req: >= 5)

Gene RIFs: 452   (req: > 3)

Antibodies: 705   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0