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Tbio
DPYSL4
Dihydropyrimidinase-related protein 4

Protein Summary
Description
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338492
  • ENSP00000339850
  • ENSG00000151640

Symbol
  • CRMP3
  • ULIP4
  • CRMP3
  • DRP-4
  • ULIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.8
transcription factor perturbation
0.8
disease perturbation
0.68
transcription factor
0.57
small molecule perturbation
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
MAP4K2
Tchem
Family:  Kinase
Novelty:  0.02195042
p_int:  0.999999953
p_ni:  1e-9
p_wrong:  4.6e-8
Data Source:  BioPlex
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
p_int:  0.999999153
p_ni:  8.47e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
p_int:  0.999998927
p_ni:  0.000001073
Data Source:  BioPlex
DPYSL3
Tbio
Family:  Enzyme
Novelty:  0.01284077
p_int:  0.999998162
p_ni:  0.000001838
Score:  0.957
Data Source:  BioPlex,STRINGDB
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
p_int:  0.999965067
p_ni:  0.000034933
Score:  0.935
Data Source:  BioPlex,STRINGDB
DPYSL2
Tbio
Family:  Enzyme
Novelty:  0.00374969
p_int:  0.999387081
p_ni:  0.000612919
Score:  0.916
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.998845157
p_ni:  0.001154843
Data Source:  BioPlex
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.996985194
p_ni:  0.001989336
p_wrong:  0.00102547
Data Source:  BioPlex
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.996721106
p_ni:  0.003262091
p_wrong:  0.000016803
Data Source:  BioPlex
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.993331433
p_ni:  0.006668566
p_wrong:  2e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
61
biological sex
1
1
1
55.2
body height
1
1
1
52.4
visceral adipose tissue measurement
1
1
1
49.5
risk-taking behaviour
1
2
2
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
61
biological sex
1
55.2
body height
1
52.4
visceral adipose tissue measurement
1
49.5
risk-taking behaviour
2
45.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 4
VGNC:3838
450833
Macaque
dihydropyrimidinase like 4
722689
Mouse
MGI:1349764
26757
Rat
RGD:2409
25417
Dog
dihydropyrimidinase like 4
VGNC:49877
491588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 4
Macaque
dihydropyrimidinase like 4
Mouse
Rat
Dog
dihydropyrimidinase like 4
Publication Statistics
PubMed Score 22.95
PubMed score by year
PubTator Score 10.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title