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Tbio
CUX2
Homeobox protein cut-like 2

Protein Summary
Description
May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity). This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261726
  • ENSP00000261726
  • ENSG00000111249

Symbol
  • CUTL2
  • KIAA0293
  • CDP2
  • CUTL2
  • EIEE67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
biological process
0.86
protein domain
0.73
cellular component
0.61
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (110)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
5
5
5.3
99.3
high density lipoprotein cholesterol measurement
7
6
9
98.5
platelet crit
2
3
4
98.2
serum gamma-glutamyl transferase measurement
4
4
5
97.6
5
5
2
1.2
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5.3
99.3
high density lipoprotein cholesterol measurement
9
98.5
platelet crit
4
98.2
serum gamma-glutamyl transferase measurement
5
97.6
2
1.2
97.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107321
13048
Rat
RGD:1305967
288665
Dog
cut like homeobox 2
VGNC:39739
486267
Cow
cut like homeobox 2
VGNC:27840
524491
Opossum
cut like homeobox 2
100018653
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cut like homeobox 2
Cow
cut like homeobox 2
Opossum
cut like homeobox 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14529-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (64)
1 – 10 of 64
FEZF2
Tbio
Family:  TF
Novelty:  0.01641588
Score:  0.742
Data Source:  STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
Score:  0.669
Data Source:  STRINGDB
TBR1
Tbio
Family:  TF
Novelty:  0.00676736
Score:  0.647
Data Source:  STRINGDB
PHETA1
Tbio
Novelty:  0.52415295
Score:  0.64
Data Source:  STRINGDB
ETV1
Tbio
Family:  TF
Novelty:  0.0055085
Score:  0.628
Data Source:  STRINGDB
TSPEAR
Tbio
Novelty:  0.15908638
Score:  0.618
Data Source:  STRINGDB
TRIM24
Tchem
Family:  Epigenetic
Novelty:  0.00532747
Score:  0.611
Data Source:  STRINGDB
BCL11B
Tbio
Family:  TF
Novelty:  0.00555596
Score:  0.593
Data Source:  STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
Score:  0.578
Data Source:  STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
Score:  0.552
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.46

PubMed score by year
PubTator Score  58.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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