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Tdark
NEMP1
Nuclear envelope integral membrane protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300128
  • ENSP00000300128
  • ENSG00000166881
  • ENST00000379391
  • ENSP00000368701

Symbol
  • KIAA0286
  • TMEM194
  • TMEM194A
  • TMEM194
  • TMEM194A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
8
0
1.1
96.4
5
2
2
1.1
86.8
eosinophil count
2
3
3
85.6
adult onset asthma
2
2
0
1.1
84.1
5
1
0
1.1
84
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96.4
2
1.1
86.8
eosinophil count
3
85.6
adult onset asthma
0
1.1
84.1
0
1.1
84
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear envelope integral membrane protein 1
VGNC:5500
452003
Mouse
MGI:2446113
210035
Dog
nuclear envelope integral membrane protein 1
VGNC:43742
607350
Horse
nuclear envelope integral membrane protein 1
VGNC:20683
100052778
Cow
nuclear envelope integral membrane protein 1
533988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear envelope integral membrane protein 1
Mouse
Dog
nuclear envelope integral membrane protein 1
Horse
nuclear envelope integral membrane protein 1
Cow
nuclear envelope integral membrane protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O14524-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (50)
1 – 10 of 50
RGPD2
Tdark
Novelty:  0.02695062
p_int:  0.999999958
p_ni:  3.9e-8
p_wrong:  3e-9
Score:  0.848
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999999704
p_ni:  2.96e-7
Score:  0.33
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.999999486
p_ni:  5.13e-7
p_wrong:  1e-9
Data Source:  BioPlex
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.999985358
p_ni:  0.000014642
Score:  0.201
Data Source:  BioPlex,STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.998253874
p_ni:  0.001746126
Score:  0.842
Data Source:  BioPlex,STRINGDB
DLGAP5
Tbio
Novelty:  0.01673312
p_int:  0.997209483
p_ni:  0.002729037
p_wrong:  0.00006148
Score:  0.718
Data Source:  BioPlex,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
p_int:  0.996694651
p_ni:  0.003305349
Score:  0.858
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.995104508
p_ni:  0.004895492
Data Source:  BioPlex
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.993181067
p_ni:  0.006421302
p_wrong:  0.000397631
Score:  0.179
Data Source:  BioPlex,STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
p_int:  0.988951893
p_ni:  0.011048107
Score:  0.873
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.95

PubMed score by year
PubTator Score  0.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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