Tdark NEMP1 Nuclear envelope integral membrane protein 1

Protein Summary

Uniprot Accession IDs

• O14524
• Q17R72
• Q68DH0
• Q6IQ25

Gene Name

• NEMP1

Ensembl ID

• ENST00000300128
• ENSP00000300128
• ENSG00000166881
• ENST00000379391
• ENSP00000368701

Symbol

• KIAA0286
• TMEM194
• TMEM194A
• TMEM194
• TMEM194A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (43)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 43

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	11	8	0	1.1	96.4
allergy	EFO_0003785	5	2	2	1.1	86.8
eosinophil count	EFO_0004842	2	3	3		85.6
adult onset asthma	EFO_1002011	2	2	0	1.1	84.1
migraine disorder	EFO_0003821	5	1	0	1.1	84

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 43

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	0	1.1	96.4
allergy	EFO_0003785	2	1.1	86.8
eosinophil count	EFO_0004842	3		85.6
adult onset asthma	EFO_1002011	0	1.1	84.1
migraine disorder	EFO_0003821	0	1.1	84

Reset Zoom  Beta Count   Odds Ratio

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nuclear envelope integral membrane protein 1	VGNC:5500	452003
Mouse	nuclear envelope integral membrane protein 1	MGI:2446113	210035
Dog	nuclear envelope integral membrane protein 1	VGNC:43742	607350
Horse	nuclear envelope integral membrane protein 1	VGNC:20683	100052778
Cow	nuclear envelope integral membrane protein 1		533988

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nuclear envelope integral membrane protein 1
Mouse	nuclear envelope integral membrane protein 1
Dog	nuclear envelope integral membrane protein 1
Horse	nuclear envelope integral membrane protein 1
Cow	nuclear envelope integral membrane protein 1

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O14524-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)

Components (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
nuclear envelope	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
nuclear inner membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (50)

Explore Interacting Targets

1 – 10 of 50

• See Interactions on String-DB

RGPD2

Tdark

Novelty:  0.02695062

p_int:  0.999999958

p_ni:  3.9e-8

p_wrong:  3e-9

Score:  0.848

Data Source:  BioPlex,STRINGDB

RGPD8

Tdark

Novelty:  0.12397737

p_int:  0.999999704

p_ni:  2.96e-7

Score:  0.33

Data Source:  BioPlex,STRINGDB

ADCY9

Tbio

Family:  Enzyme

Novelty:  0.00744116

p_int:  0.999999486

p_ni:  5.13e-7

p_wrong:  1e-9

Data Source:  BioPlex

RGPD5

Tbio

Novelty:  0.13776125

p_int:  0.999985358

p_ni:  0.000014642

Score:  0.201

Data Source:  BioPlex,STRINGDB

RAN

Tchem

Family:  Enzyme

Novelty:  0.00160888

p_int:  0.998253874

p_ni:  0.001746126

Score:  0.842

Data Source:  BioPlex,STRINGDB

DLGAP5

Tbio

Novelty:  0.01673312

p_int:  0.997209483

p_ni:  0.002729037

p_wrong:  0.00006148

Score:  0.718

Data Source:  BioPlex,STRINGDB

RANBP2

Tbio

Family:  Enzyme

Novelty:  0.00484823

p_int:  0.996694651

p_ni:  0.003305349

Score:  0.858

Data Source:  BioPlex,STRINGDB

ACAD11

Tbio

Family:  Enzyme

Novelty:  0.22908145

p_int:  0.995104508

p_ni:  0.004895492

Data Source:  BioPlex

GLRB

Tclin

Family:  IC

Novelty:  0.01721113

p_int:  0.993181067

p_ni:  0.006421302

p_wrong:  0.000397631

Score:  0.179

Data Source:  BioPlex,STRINGDB

RANGAP1

Tbio

Family:  Enzyme

Novelty:  0.00917672

p_int:  0.988951893

p_ni:  0.011048107

Score:  0.873

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  4.95

PubMed score by year

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PubTator Score  0.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Signal
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
adult onset asthma
age at onset
alcohol consumption measurement
allergic rhinitis
allergic sensitization measurement
allergy
Anilide use measurement
Antihistamine use measurement
Antimigraine preparation use measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
reproductive system phenotype