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Tbio
PTPRT
Receptor-type tyrosine-protein phosphatase T

Protein Summary
Description
May be involved in both signal transduction and cellular adhesion in the CNS. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
PubMedID
0.8
microRNA
0.75
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.69   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.69   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.789
Data Source:  STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.682
Data Source:  STRINGDB
SLITRK1
Tbio
Novelty:  0.0132455
Score:  0.654
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.622
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.614
Data Source:  STRINGDB
SLITRK2
Tbio
Novelty:  0.18828177
Score:  0.602
Data Source:  STRINGDB
MYO3B
Tchem
Family:  Kinase
Novelty:  0.1365033
Score:  0.556
Data Source:  STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.556
Data Source:  STRINGDB
BCR
Tclin
Novelty:  0.00127709
Score:  0.542
Data Source:  STRINGDB
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
Score:  0.536
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
WikiPathways
Regulatory circuits of the STAT3 signaling pathway
Name
Explore in Pharos
Explore in Source
Regulatory circuits of the STAT3 signaling pathway
Regulatory circuits of the STAT3 signaling pathway
Regulatory circuits of the STAT3 signaling pathway
Regulatory circuits of the STAT3 signaling pathway
Regulatory circuits of the STAT3 signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
4
74
self reported educational attainment
2
2
2
67.5
cognitive function measurement
1
1
1
53.7
household income
1
1
1
28.1
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
74
self reported educational attainment
2
67.5
cognitive function measurement
1
53.7
household income
1
28.1
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type T
VGNC:9945
458258
Macaque
protein tyrosine phosphatase, receptor type T
696796
Mouse
MGI:1321152
19281
Dog
protein tyrosine phosphatase, receptor type T
VGNC:45199
485878
Anole lizard
protein tyrosine phosphatase, receptor type T
100554877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type T
Macaque
protein tyrosine phosphatase, receptor type T
Mouse
Dog
protein tyrosine phosphatase, receptor type T
Anole lizard
protein tyrosine phosphatase, receptor type T
Publication Statistics
PubMed Score 33.69
PubMed score by year
PubTator Score 36.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title