Tbio SDHD Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Protein Summary

Description

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• O14521
• A6ND90
• B3KQQ8
• E9PIC0
• E9PIG3
• E9PQI9
• Q53XW5
• Q6IRW2
• CybS

Gene Name

• SDHD

Ensembl ID

• ENST00000375549
• ENSP00000364699
• ENSG00000204370
• ENST00000525291
• ENSP00000436669
• ENST00000526592
• ENSP00000432005
• ENST00000528048
• ENSP00000436217
• ENST00000614349
• ENSP00000480666

Symbol

• SDH4
• PGL
• CBT1
• CWS3
• PGL1
• QPs3
• SDH4
• cybS
• CII-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
histone modification site profile	0.93
kinase perturbation	0.93
cellular component	0.9
phenotype	0.81

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial

DTO Classes

Protein / Transporter / Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.33   (req: < 5)

Gene RIFs: 99   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.33   (req: >= 5)

Gene RIFs: 99   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (186)

Explore Interacting Targets

1 – 10 of 186

• See Interactions on String-DB

DHODH

Tclin

Family:  Enzyme

Novelty:  0.00217565

p_int:  0.999999871

p_ni:  4.2e-8

p_wrong:  8.7e-8

Data Source:  BioPlex

SRC

Tclin

Family:  Kinase

Novelty:  0.00008479

p_int:  0.99881591

p_ni:  0.001184078

p_wrong:  1.2e-8

Data Source:  BioPlex

IL17F

Tbio

Novelty:  0.00223549

p_int:  0.998047936

p_ni:  0.00139865

p_wrong:  0.000553414

Data Source:  BioPlex

SPECC1L

Tbio

Novelty:  0.06116909

p_int:  0.981961659

p_ni:  0.018038341

Data Source:  BioPlex

RAP1A

Tchem

Family:  Enzyme

Novelty:  0.00375413

p_int:  0.911067886

p_ni:  0.084267016

p_wrong:  0.004665099

Data Source:  BioPlex

SDHC

Tbio

Family:  Enzyme

Novelty:  0.0005776

p_int:  0.903124856

p_ni:  0.000005764

p_wrong:  0.09686938

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SDHB

Tchem

Family:  Enzyme

Novelty:  0.0010199

p_int:  0.888896436

p_ni:  0.111103564

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACTA2

Tbio

Novelty:  0.00199354

p_int:  0.867440468

p_ni:  0.132559532

Data Source:  BioPlex

GNG5

Tbio

Novelty:  0.1525101

p_int:  0.849647887

p_ni:  0.150340799

p_wrong:  0.000011314

Data Source:  BioPlex

SDHA

Tbio

Family:  Enzyme

Novelty:  0.00223171

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

IDH2

Tclin

Family:  Enzyme

KEGG Distance:  4

Common Pathways:  3

1: Citrate cycle (TCA cycle)

2: Carbon metabolism

3: Metabolic pathways

Pathways (19)

Reactome (6)

KEGG (9)

UniProt (1)

WikiPathways (3)

Citric acid cycle (TCA cycle) (R-HSA-71403)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Citric acid cycle (TCA cycle)	22 targets	R-HSA-71403
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Name	Explore in Pharos	Explore in Source
Citric acid cycle (TCA cycle)	22 targets	R-HSA-71403
Metabolism	2112 targets	R-HSA-1430728
Pyruvate metabolism and Citric Acid (TCA) cycle	55 targets	R-HSA-71406
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (5)

Components (5)

Processes (2)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
succinate dehydrogenase activity	Inferred from Direct Assay (IDA)	UniProtKB
heme binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ubiquinone binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
electron transfer activity	Traceable Author Statement (TAS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (10)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin 18 measurement	EFO_0004581	3	3	3		98.1
waist-hip ratio	EFO_0004343	2	2	2		83
blood protein measurement	EFO_0007937	1	1	1		80.8
interleukin 1 receptor antagonist measurement	EFO_0004754	1	1	1		80.5
interleukin-1 beta measurement	EFO_0004812	1	1	1		80.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin 18 measurement	EFO_0004581	3		98.1
waist-hip ratio	EFO_0004343	2		83
blood protein measurement	EFO_0007937	1		80.8
interleukin 1 receptor antagonist measurement	EFO_0004754	1		80.5
interleukin-1 beta measurement	EFO_0004812	1		80.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
interleukin 1 receptor antagonist measurement
interleukin 18 measurement
interleukin-1 beta measurement
risk-taking behaviour
smoking initiation
smoking status measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	succinate dehydrogenase complex subunit D		106992278
Mouse	succinate dehydrogenase complex, subunit D, integral membrane protein	MGI:1914175	66925
Rat	succinate dehydrogenase complex subunit D	RGD:735231	363061
Cow	succinate dehydrogenase complex subunit D		281481
Pig	succinate dehydrogenase complex subunit D		100048954

Species	Name	OMA	EggNOG	Inparanoid
Macaque	succinate dehydrogenase complex subunit D
Mouse	succinate dehydrogenase complex, subunit D, integral membrane protein
Rat	succinate dehydrogenase complex subunit D
Cow	succinate dehydrogenase complex subunit D
Pig	succinate dehydrogenase complex subunit D

Publication Statistics

PubMed Score 623.33

PubMed score by year

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PubTator Score 261.19

PubTator score by year

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Related Publications

Text Mined References (141)

GeneRif Annotations (99)

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PMID	Year	Title