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Tbio
SDHD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Protein Summary
Description
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375549
  • ENSP00000364699
  • ENSG00000204370
  • ENST00000525291
  • ENSP00000436669
  • ENST00000526592
  • ENSP00000432005
  • ENST00000528048
  • ENSP00000436217
  • ENST00000614349
  • ENSP00000480666

Symbol
  • SDH4
  • PGL
  • CBT1
  • CWS3
  • PGL1
  • QPs3
  • SDH4
  • cybS
  • CII-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.93
kinase perturbation
0.93
cellular component
0.9
phenotype
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.33   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.33   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
DHODH
Tclin
Family:  Enzyme
Novelty:  0.00217565
p_int:  0.999999871
p_ni:  4.2e-8
p_wrong:  8.7e-8
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.99881591
p_ni:  0.001184078
p_wrong:  1.2e-8
Data Source:  BioPlex
IL17F
Tbio
Novelty:  0.00223549
p_int:  0.998047936
p_ni:  0.00139865
p_wrong:  0.000553414
Data Source:  BioPlex
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.981961659
p_ni:  0.018038341
Data Source:  BioPlex
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.911067886
p_ni:  0.084267016
p_wrong:  0.004665099
Data Source:  BioPlex
SDHC
Tbio
Family:  Enzyme
Novelty:  0.0005776
p_int:  0.903124856
p_ni:  0.000005764
p_wrong:  0.09686938
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.888896436
p_ni:  0.111103564
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.867440468
p_ni:  0.132559532
Data Source:  BioPlex
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.849647887
p_ni:  0.150340799
p_wrong:  0.000011314
Data Source:  BioPlex
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
Score:  0.999
Data Source:  Reactome,STRINGDB
Pathways (19)
Citric acid cycle (TCA cycle) (R-HSA-71403)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
3
3
98.1
waist-hip ratio
2
2
2
83
blood protein measurement
1
1
1
80.8
interleukin 1 receptor antagonist measurement
1
1
1
80.5
interleukin-1 beta measurement
1
1
1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
98.1
waist-hip ratio
2
83
blood protein measurement
1
80.8
interleukin 1 receptor antagonist measurement
1
80.5
interleukin-1 beta measurement
1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
succinate dehydrogenase complex subunit D
106992278
Mouse
MGI:1914175
66925
Rat
RGD:735231
363061
Cow
succinate dehydrogenase complex subunit D
281481
Pig
succinate dehydrogenase complex subunit D
100048954
Species
Name
OMA
EggNOG
Inparanoid
Macaque
succinate dehydrogenase complex subunit D
Mouse
Rat
Cow
succinate dehydrogenase complex subunit D
Pig
succinate dehydrogenase complex subunit D
Publication Statistics
PubMed Score 623.33
PubMed score by year
PubTator Score 261.19
PubTator score by year
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Related Publications
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PMID
Year
Title