Tbio AQP7 Aquaporin-7

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-7

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-7

Protein Summary

Description

Forms a channel for water and glycerol. This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O14520
• Q08E94
• Q5T5L9
• Q8NHM3
• AQP-7

Gene Name

• AQP7

Ensembl ID

• ENST00000297988
• ENSP00000297988
• ENSG00000165269
• ENST00000447660
• ENSP00000412868

Symbol

• AQP7L
• AQP9
• AQP7L
• AQPap
• GLYCQTL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	0.68
molecular function	0.67
kinase perturbation	0.6
cell type or tissue	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.94   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.94   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (7)

Reactome (4)

KEGG (2)

WikiPathways (1)

Aquaporin-mediated transport (R-HSA-445717)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047
Reactome	Transport of glycerol from adipocytes to the liver by Aquaporins	2 targets	R-HSA-432030
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Passive transport by Aquaporins	13 targets	R-HSA-432047
Transport of glycerol from adipocytes to the liver by Aquaporins	2 targets	R-HSA-432030
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (10)

Functions (2)

Components (4)

Processes (4)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
glycerol channel activity	Inferred from Experiment (EXP)	Reactome
water channel activity	Inferred from Experiment (EXP)	Reactome

Protein-Protein Interactions (20)

Explore Interacting Targets

1 – 10 of 20

• See Interactions on String-DB

AQP12A

Tbio

Novelty: 0.0840303

Score: 0.865

Data Source: STRINGDB

AQP11

Tbio

Novelty: 0.02650569

Score: 0.827

Data Source: STRINGDB

GK

Tbio

Family: Kinase

Novelty: 0.00835719

Score: 0.681

Data Source: STRINGDB

INS

Tbio

Novelty: 0.00000614

Score: 0.64

Data Source: STRINGDB

LEP

Tbio

Novelty: 0.0000644

Score: 0.582

Data Source: STRINGDB

AQP12B

Tdark

Novelty: 0.75471698

Score: 0.548

Data Source: STRINGDB

PLIN1

Tbio

Novelty: 0.00171066

Score: 0.536

Data Source: STRINGDB

AQP1

Tbio

Novelty: 0.000781

Score: 0.499

Data Source: STRINGDB

AQP8

Tbio

Novelty: 0.00760952

Score: 0.482

Data Source: STRINGDB

KCNJ10

Tbio

Family: IC

Novelty: 0.00337611

Score: 0.477

Data Source: STRINGDB

Publication Statistics

PubMed Score  184.94

PubMed score by year

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PubTator Score  66.84

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGV

1-70

NLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILH

70-140

FSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILV

140-210

VIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTI

210-280

PREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF

280-342

MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF

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Uniprot Keyword

Alternative splicing
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport