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Tbio
AQP7
Aquaporin-7

Protein Summary
Description
Forms a channel for water and glycerol. This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297988
  • ENSP00000297988
  • ENSG00000165269
  • ENST00000447660
  • ENSP00000412868

Symbol
  • AQP7L
  • AQP9
  • AQP7L
  • AQPap
  • GLYCQTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.68
molecular function
0.67
kinase perturbation
0.6
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.16   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.16   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.865
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.827
Data Source:  STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
Score:  0.681
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.64
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.582
Data Source:  STRINGDB
AQP12B
Tdark
Novelty:  0.40546451
Score:  0.548
Data Source:  STRINGDB
PLIN1
Tbio
Novelty:  0.00200378
Score:  0.536
Data Source:  STRINGDB
AQP1
Tbio
Novelty:  0.00067935
Score:  0.499
Data Source:  STRINGDB
AQP8
Tbio
Novelty:  0.00613662
Score:  0.482
Data Source:  STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
Score:  0.477
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of glycerol from adipocytes to the liver by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of glycerol from adipocytes to the liver by Aquaporins
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
1
1
24.5
glucose measurement
1
1
1
6.1
1
1
0
1.1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
24.5
glucose measurement
1
6.1
0
1.1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
aquaporin 7
702836
Mouse
MGI:1314647
11832
Rat
RGD:2145
29171
Dog
aquaporin 7
474742
Horse
aquaporin 7
100068324
Species
Name
OMA
EggNOG
Inparanoid
Macaque
aquaporin 7
Mouse
Rat
Dog
aquaporin 7
Horse
aquaporin 7
Publication Statistics
PubMed Score 252.16
PubMed score by year
PubTator Score 66.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title