Protein Summary
Forms a channel for water and glycerol. This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]
- ENST00000297988
- ENSP00000297988
- ENSG00000165269
- ENST00000447660
- ENSP00000412868
- AQP7L
- AQP9
- AQP7L
- AQPap
- GLYCQTL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
disease perturbation | 0.68 | ||
molecular function | 0.67 | ||
kinase perturbation | 0.6 | ||
cell type or tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.16 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.16 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (20)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of glycerol from adipocytes to the liver by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of glycerol from adipocytes to the liver by Aquaporins | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
albuminuria | 1 | 1 | 1 | 24.5 | |||||
glucose measurement | 1 | 1 | 1 | 6.1 | |||||
1 | 1 | 0 | 1.1 | 1.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
albuminuria | 1 | 24.5 | |||||
glucose measurement | 1 | 6.1 | |||||
0 | 1.1 | 1.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | aquaporin 7 | 702836 | ||||||
Mouse | MGI:1314647 | 11832 | ||||||
Rat | RGD:2145 | 29171 | ||||||
Dog | aquaporin 7 | 474742 | ||||||
Horse | aquaporin 7 | 100068324 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | aquaporin 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | aquaporin 7 | |||||
Horse | aquaporin 7 | |||||
Publication Statistics
PubMed Score 252.16
PubMed score by year
PubTator Score 66.84
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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