Tbio CDK2AP1 Cyclin-dependent kinase 2-associated protein 1

Protein Summary

Description

specific inhibitor of the cell-cycle kinase CDK2. The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• O14519
• F5GYA4
• CDK2-associated protein 1

Gene Name

• CDK2AP1

Ensembl ID

• ENST00000261692
• ENSP00000261692
• ENSG00000111328
• ENST00000535979
• ENSP00000442565
• ENST00000538446
• ENSP00000442502
• ENST00000542174
• ENSP00000440729
• ENST00000544658
• ENSP00000438561
• ENST00000618072
• ENSP00000479982

Symbol

• CDKAP1
• DOC1
• DOC1
• ST19
• DORC1
• doc-1
• p12DOC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.97
transcription factor perturbation	0.74
PubMedID	0.73
interacting protein	0.72

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Cyclin-dependent Kinase 2-associated Protein 1

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Cyclin-dependent Kinase 2-associated Protein 1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Cyclin-dependent Kinase 2-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.22   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.22   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0