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Tbio
CDK2AP1
Cyclin-dependent kinase 2-associated protein 1

Protein Summary
Description
specific inhibitor of the cell-cycle kinase CDK2. The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261692
  • ENSP00000261692
  • ENSG00000111328
  • ENST00000535979
  • ENSP00000442565
  • ENST00000538446
  • ENSP00000442502
  • ENST00000542174
  • ENSP00000440729
  • ENST00000544658
  • ENSP00000438561
  • ENST00000618072
  • ENSP00000479982

Symbol
  • CDKAP1
  • DOC1
  • DOC1
  • ST19
  • DORC1
  • doc-1
  • p12DOC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
transcription factor perturbation
0.74
PubMedID
0.73
interacting protein
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.37   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.37   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
2
2
6.7
98.9
mathematical ability
3
3
3
98.8
cognitive function measurement
1
1
1
88.5
heel bone mineral density
2
2
2
87
1
1
1
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
6.7
98.9
mathematical ability
3
98.8
cognitive function measurement
1
88.5
heel bone mineral density
2
87
1
82.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 2 associated protein 1
VGNC:8365
452342
Macaque
cyclin dependent kinase 2 associated protein 1
704412
Mouse
MGI:1202069
13445
Mouse
MGI:3652174
100039945
Rat
RGD:1308664
360804
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 2 associated protein 1
Macaque
cyclin dependent kinase 2 associated protein 1
Mouse
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14519-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
CHD5
Tbio
Family: Epigenetic
Novelty: 0.06408395
p_int: 0.999999975
p_ni: 2.5e-8
Score: 0.17
Data Source: BioPlex,STRINGDB
MBD3
Tbio
Family: TF
Novelty: 0.04513502
p_int: 0.999997483
p_ni: 0.000002517
Score: 0.79
Data Source: BioPlex,STRINGDB
MBD3L1
Tbio
Novelty: 0.11297566
p_int: 0.999993169
p_ni: 0.000006812
p_wrong: 1.8e-8
Score: 0.874
Data Source: BioPlex,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999992285
p_ni: 0.000007694
p_wrong: 2.1e-8
Score: 0.223
Data Source: BioPlex,STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999991791
p_ni: 0.000008209
Data Source: BioPlex
MTA3
Tbio
Family: TF
Novelty: 0.02667635
p_int: 0.999991459
p_ni: 0.000008541
Score: 0.665
Data Source: BioPlex,STRINGDB
MRFAP1L1
Tdark
Novelty: 0.87470289
p_int: 0.999991105
p_ni: 0.000001414
p_wrong: 0.000007481
Score: 0.212
Data Source: BioPlex,STRINGDB
MBD2
Tchem
Family: TF
Novelty: 0.01209635
p_int: 0.999990006
p_ni: 0.000009989
p_wrong: 6e-9
Score: 0.818
Data Source: BioPlex,STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
p_int: 0.999984839
p_ni: 0.000015161
Score: 0.482
Data Source: BioPlex,STRINGDB
MTA1
Tbio
Family: TF
Novelty: 0.00464618
p_int: 0.999984463
p_ni: 0.000015538
Score: 0.464
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  70.37

PubMed score by year
PubTator Score  58.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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