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Tbio
ADGRB1
Adhesion G protein-coupled receptor B1

Protein Summary
Description
Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of gliobla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323289
  • ENSP00000313046
  • ENSG00000181790
  • ENST00000517894
  • ENSP00000430945

Symbol
  • BAI1
  • BAI1
  • GDAIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell line
0.72
PubMedID
0.59
gene perturbation
0.53
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (49)
1 – 10 of 49
ELMO1
Tbio
Novelty: 0.01956016
Score: 0.907
Data Source: STRINGDB
TIMD4
Tbio
Novelty: 0.01185376
Score: 0.772
Data Source: STRINGDB
BAIAP3
Tbio
Novelty: 0.04173561
Score: 0.767
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00079421
Score: 0.742
Data Source: STRINGDB
STAB2
Tbio
Novelty: 0.0081507
Score: 0.736
Data Source: STRINGDB
MAGI1
Tbio
Family: Enzyme
Novelty: 0.08313489
Score: 0.707
Data Source: STRINGDB
DOCK1
Tbio
Novelty: 0.0121148
Score: 0.694
Data Source: STRINGDB
BAIAP2
Tbio
Novelty: 0.01187433
Score: 0.685
Data Source: STRINGDB
ELMO2
Tbio
Novelty: 0.08787898
Score: 0.684
Data Source: STRINGDB
MFGE8
Tbio
Novelty: 0.00173389
Score: 0.674
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.63

PubMed score by year
PubTator Score  34.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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