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Tbio
SOCS2
Suppressor of cytokine signaling 2

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including eryt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340600
  • ENSP00000339428
  • ENSG00000120833
  • ENST00000536696
  • ENSP00000442898
  • ENST00000549122
  • ENSP00000447161
  • ENST00000549206
  • ENSP00000448815
  • ENST00000551556
  • ENSP00000449227
  • ENST00000622746
  • ENSP00000481249

Symbol
  • CIS2
  • SSI2
  • STATI2
  • CIS2
  • SSI2
  • Cish2
  • SSI-2
  • SOCS-2
  • STATI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.97
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.23   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.23   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
97.8
body height
5
4
6
96.6
testosterone measurement
2
2
2
61.4
sex hormone-binding globulin measurement
2
1
2
15.9
anthropometric measurement
1
1
0
1.3
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
97.8
body height
6
96.6
testosterone measurement
2
61.4
sex hormone-binding globulin measurement
2
15.9
anthropometric measurement
0
1.3
4.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 2
VGNC:5593
452127
Mouse
MGI:1201787
216233
Mouse
MGI:3642840
100043256
Rat
RGD:69273
84607
Dog
suppressor of cytokine signaling 2
VGNC:46649
100855737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 2
Mouse
Mouse
Rat
Dog
suppressor of cytokine signaling 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14508-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Interleukin-7 signaling
Metabolism of proteins
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (223)
1 – 10 of 223
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.999999822
p_ni: 1.78e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.999999744
p_ni: 2.9e-8
p_wrong: 2.28e-7
Score: 0.963
Data Source: BioPlex,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.997
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.997
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.984
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.983
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.982
Data Source: STRINGDB
GHR
Tclin
Novelty: 0.00105635
Score: 0.97
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.962
Data Source: STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  247.23

PubMed score by year
PubTator Score  410.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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