Tbio SOCS2 Suppressor of cytokine signaling 2

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• O14508
• A8K3D1
• O14542
• O95102
• Q9UKS5
• SOCS-2

Gene Name

• SOCS2

Ensembl ID

• ENST00000340600
• ENSP00000339428
• ENSG00000120833
• ENST00000536696
• ENSP00000442898
• ENST00000549122
• ENSP00000447161
• ENST00000549206
• ENSP00000448815
• ENST00000551556
• ENSP00000449227
• ENST00000622746
• ENSP00000481249

Symbol

• CIS2
• SSI2
• STATI2
• CIS2
• SSI2
• Cish2
• SSI-2
• SOCS-2
• STATI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
PubMedID	1
transcription factor perturbation	0.99
transcription factor binding site profile	0.97
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 2

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.41   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.41   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0